Progressive Left Ventricular Outflow Tract Stenosis in a Noonan Syndrome Patient With Severe Hypertrophic Cardiomyopathy During Growth Hormone Treatment

Short stature is a main problem in Noonan syndrome (NS). Recombinant human growth hormone (GH) has been used to safely improve the growth rate in NS patients with short stature. However, there is little information about GH therapy for NS associated with hypertrophic obstructive cardiomyopathy. We p...

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Autores principales: Ichikawa, Yasuhiro, Saito, Naka, Kurosawa, Kenji, Hanakawa, Junko, Ueda, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079321/
https://www.ncbi.nlm.nih.gov/pubmed/35535293
http://dx.doi.org/10.7759/cureus.23937
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author Ichikawa, Yasuhiro
Saito, Naka
Kurosawa, Kenji
Hanakawa, Junko
Ueda, Hideaki
author_facet Ichikawa, Yasuhiro
Saito, Naka
Kurosawa, Kenji
Hanakawa, Junko
Ueda, Hideaki
author_sort Ichikawa, Yasuhiro
collection PubMed
description Short stature is a main problem in Noonan syndrome (NS). Recombinant human growth hormone (GH) has been used to safely improve the growth rate in NS patients with short stature. However, there is little information about GH therapy for NS associated with hypertrophic obstructive cardiomyopathy. We present the case of a seven-year-old NS patient with severe hypertrophic obstructive cardiomyopathy. The patient received GH therapy for six months, at which time progressive left ventricular outflow tract stenosis was apparent.
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spelling pubmed-90793212022-05-08 Progressive Left Ventricular Outflow Tract Stenosis in a Noonan Syndrome Patient With Severe Hypertrophic Cardiomyopathy During Growth Hormone Treatment Ichikawa, Yasuhiro Saito, Naka Kurosawa, Kenji Hanakawa, Junko Ueda, Hideaki Cureus Cardiology Short stature is a main problem in Noonan syndrome (NS). Recombinant human growth hormone (GH) has been used to safely improve the growth rate in NS patients with short stature. However, there is little information about GH therapy for NS associated with hypertrophic obstructive cardiomyopathy. We present the case of a seven-year-old NS patient with severe hypertrophic obstructive cardiomyopathy. The patient received GH therapy for six months, at which time progressive left ventricular outflow tract stenosis was apparent. Cureus 2022-04-07 /pmc/articles/PMC9079321/ /pubmed/35535293 http://dx.doi.org/10.7759/cureus.23937 Text en Copyright © 2022, Ichikawa et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Ichikawa, Yasuhiro
Saito, Naka
Kurosawa, Kenji
Hanakawa, Junko
Ueda, Hideaki
Progressive Left Ventricular Outflow Tract Stenosis in a Noonan Syndrome Patient With Severe Hypertrophic Cardiomyopathy During Growth Hormone Treatment
title Progressive Left Ventricular Outflow Tract Stenosis in a Noonan Syndrome Patient With Severe Hypertrophic Cardiomyopathy During Growth Hormone Treatment
title_full Progressive Left Ventricular Outflow Tract Stenosis in a Noonan Syndrome Patient With Severe Hypertrophic Cardiomyopathy During Growth Hormone Treatment
title_fullStr Progressive Left Ventricular Outflow Tract Stenosis in a Noonan Syndrome Patient With Severe Hypertrophic Cardiomyopathy During Growth Hormone Treatment
title_full_unstemmed Progressive Left Ventricular Outflow Tract Stenosis in a Noonan Syndrome Patient With Severe Hypertrophic Cardiomyopathy During Growth Hormone Treatment
title_short Progressive Left Ventricular Outflow Tract Stenosis in a Noonan Syndrome Patient With Severe Hypertrophic Cardiomyopathy During Growth Hormone Treatment
title_sort progressive left ventricular outflow tract stenosis in a noonan syndrome patient with severe hypertrophic cardiomyopathy during growth hormone treatment
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079321/
https://www.ncbi.nlm.nih.gov/pubmed/35535293
http://dx.doi.org/10.7759/cureus.23937
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