Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations perfor...

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Autores principales: Du, Li-Hua, Shen, Jia-Hong, Dong, Zhen, Zhou, Na-Ni, Cheng, Bing-Zhuo, Ou, Zhi-Min, Luo, Xi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079605/
https://www.ncbi.nlm.nih.gov/pubmed/35541271
http://dx.doi.org/10.1039/c8ra01030g
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author Du, Li-Hua
Shen, Jia-Hong
Dong, Zhen
Zhou, Na-Ni
Cheng, Bing-Zhuo
Ou, Zhi-Min
Luo, Xi-Ping
author_facet Du, Li-Hua
Shen, Jia-Hong
Dong, Zhen
Zhou, Na-Ni
Cheng, Bing-Zhuo
Ou, Zhi-Min
Luo, Xi-Ping
author_sort Du, Li-Hua
collection PubMed
description We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations performed in continuous flow microreactors are a proof-of-concept opening the use of enzymatic microreactors in uridine derivative biotransformations.
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spelling pubmed-90796052022-05-09 Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor Du, Li-Hua Shen, Jia-Hong Dong, Zhen Zhou, Na-Ni Cheng, Bing-Zhuo Ou, Zhi-Min Luo, Xi-Ping RSC Adv Chemistry We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations performed in continuous flow microreactors are a proof-of-concept opening the use of enzymatic microreactors in uridine derivative biotransformations. The Royal Society of Chemistry 2018-04-03 /pmc/articles/PMC9079605/ /pubmed/35541271 http://dx.doi.org/10.1039/c8ra01030g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Du, Li-Hua
Shen, Jia-Hong
Dong, Zhen
Zhou, Na-Ni
Cheng, Bing-Zhuo
Ou, Zhi-Min
Luo, Xi-Ping
Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
title Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
title_full Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
title_fullStr Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
title_full_unstemmed Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
title_short Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
title_sort enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079605/
https://www.ncbi.nlm.nih.gov/pubmed/35541271
http://dx.doi.org/10.1039/c8ra01030g
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