PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study

PURPOSE: PEGylated human hyaluronidase (PEGPH20) enzymatically depletes hyaluronan, an important component of the extracellular matrix, increasing the delivery of therapeutic molecules. Combinations of chemotherapy and PEGPH20, however, have been unsuccessful in Phase III clinical trials. We hypothe...

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Detalles Bibliográficos
Autores principales: Seki, Tomohiro, Saida, Yu, Kishimoto, Shun, Lee, Jisook, Otowa, Yasunori, Yamamoto, Kazutoshi, Chandramouli, Gadisetti VR, Devasahayam, Nallathamby, Mitchell, James B., Krishna, Murali C., Brender, Jeffery R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079680/
https://www.ncbi.nlm.nih.gov/pubmed/35523073
http://dx.doi.org/10.1016/j.neo.2022.100793

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