Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification

Expression of a neuropilin-like protein, DCBLD2, is reduced in human calcific aortic valve disease (CAVD). DCBLD2-deficient mice develop bicuspid aortic valve (BAV) and CAVD, which is more severe in BAV mice compared with tricuspid littermates. In vivo and in vitro studies link this observation to u...

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Detalles Bibliográficos
Autores principales: Jung, Jae-Joon, Ahmad, Azmi A., Rajendran, Saranya, Wei, Linyan, Zhang, Jiasheng, Toczek, Jakub, Nie, Lei, Kukreja, Gunjan, Salarian, Mani, Gona, Kiran, Ghim, Mean, Chakraborty, Raja, Martin, Kathleen A., Tellides, George, Heistad, Donald, Sadeghi, Mehran M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079798/
https://www.ncbi.nlm.nih.gov/pubmed/35540096
http://dx.doi.org/10.1016/j.jacbts.2021.12.006
Descripción
Sumario:Expression of a neuropilin-like protein, DCBLD2, is reduced in human calcific aortic valve disease (CAVD). DCBLD2-deficient mice develop bicuspid aortic valve (BAV) and CAVD, which is more severe in BAV mice compared with tricuspid littermates. In vivo and in vitro studies link this observation to up-regulated bone morphogenic protein (BMP)2 expression in the presence of DCBLD2 down-regulation, and enhanced BMP2 signaling in BAV, indicating that a combination of genetics and BAV promotes aortic valve calcification and stenosis. This pathway may be a therapeutic target to prevent CAVD progression in BAV.

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