Cargando…
Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification
Expression of a neuropilin-like protein, DCBLD2, is reduced in human calcific aortic valve disease (CAVD). DCBLD2-deficient mice develop bicuspid aortic valve (BAV) and CAVD, which is more severe in BAV mice compared with tricuspid littermates. In vivo and in vitro studies link this observation to u...
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079798/ https://www.ncbi.nlm.nih.gov/pubmed/35540096 http://dx.doi.org/10.1016/j.jacbts.2021.12.006 |
| _version_ | 1784702636474236928 |
|---|---|
| author | Jung, Jae-Joon Ahmad, Azmi A. Rajendran, Saranya Wei, Linyan Zhang, Jiasheng Toczek, Jakub Nie, Lei Kukreja, Gunjan Salarian, Mani Gona, Kiran Ghim, Mean Chakraborty, Raja Martin, Kathleen A. Tellides, George Heistad, Donald Sadeghi, Mehran M. |
| author_facet | Jung, Jae-Joon Ahmad, Azmi A. Rajendran, Saranya Wei, Linyan Zhang, Jiasheng Toczek, Jakub Nie, Lei Kukreja, Gunjan Salarian, Mani Gona, Kiran Ghim, Mean Chakraborty, Raja Martin, Kathleen A. Tellides, George Heistad, Donald Sadeghi, Mehran M. |
| author_sort | Jung, Jae-Joon |
| collection | PubMed |
| description | Expression of a neuropilin-like protein, DCBLD2, is reduced in human calcific aortic valve disease (CAVD). DCBLD2-deficient mice develop bicuspid aortic valve (BAV) and CAVD, which is more severe in BAV mice compared with tricuspid littermates. In vivo and in vitro studies link this observation to up-regulated bone morphogenic protein (BMP)2 expression in the presence of DCBLD2 down-regulation, and enhanced BMP2 signaling in BAV, indicating that a combination of genetics and BAV promotes aortic valve calcification and stenosis. This pathway may be a therapeutic target to prevent CAVD progression in BAV. |
| format | Online Article Text |
| id | pubmed-9079798 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90797982022-05-09 Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification Jung, Jae-Joon Ahmad, Azmi A. Rajendran, Saranya Wei, Linyan Zhang, Jiasheng Toczek, Jakub Nie, Lei Kukreja, Gunjan Salarian, Mani Gona, Kiran Ghim, Mean Chakraborty, Raja Martin, Kathleen A. Tellides, George Heistad, Donald Sadeghi, Mehran M. JACC Basic Transl Sci Preclinical Research Expression of a neuropilin-like protein, DCBLD2, is reduced in human calcific aortic valve disease (CAVD). DCBLD2-deficient mice develop bicuspid aortic valve (BAV) and CAVD, which is more severe in BAV mice compared with tricuspid littermates. In vivo and in vitro studies link this observation to up-regulated bone morphogenic protein (BMP)2 expression in the presence of DCBLD2 down-regulation, and enhanced BMP2 signaling in BAV, indicating that a combination of genetics and BAV promotes aortic valve calcification and stenosis. This pathway may be a therapeutic target to prevent CAVD progression in BAV. Elsevier 2022-03-23 /pmc/articles/PMC9079798/ /pubmed/35540096 http://dx.doi.org/10.1016/j.jacbts.2021.12.006 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Preclinical Research Jung, Jae-Joon Ahmad, Azmi A. Rajendran, Saranya Wei, Linyan Zhang, Jiasheng Toczek, Jakub Nie, Lei Kukreja, Gunjan Salarian, Mani Gona, Kiran Ghim, Mean Chakraborty, Raja Martin, Kathleen A. Tellides, George Heistad, Donald Sadeghi, Mehran M. Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification |
| title | Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification |
| title_full | Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification |
| title_fullStr | Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification |
| title_full_unstemmed | Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification |
| title_short | Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification |
| title_sort | differential bmp signaling mediates the interplay between genetics and leaflet numbers in aortic valve calcification |
| topic | Preclinical Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079798/ https://www.ncbi.nlm.nih.gov/pubmed/35540096 http://dx.doi.org/10.1016/j.jacbts.2021.12.006 |
| work_keys_str_mv | AT jungjaejoon differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT ahmadazmia differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT rajendransaranya differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT weilinyan differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT zhangjiasheng differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT toczekjakub differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT nielei differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT kukrejagunjan differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT salarianmani differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT gonakiran differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT ghimmean differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT chakrabortyraja differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT martinkathleena differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT tellidesgeorge differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT heistaddonald differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification AT sadeghimehranm differentialbmpsignalingmediatestheinterplaybetweengeneticsandleafletnumbersinaorticvalvecalcification |