Genetic Catalytic Inactivation of GRK5 Impairs Cardiac Function in Mice Via Dysregulated P53 Levels

GRK5’s catalytic activity in regulating basal and stressed cardiac function has not been studied. Herein, we studied knock-in mice in which GRK5 was mutated to render it catalytically inactive (K215R). At baseline, GRK5-K215R mice showed a marked decline in cardiac function with increased apoptosis...

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Detalles Bibliográficos
Autores principales: Marzano, Federica, Liccardo, Daniela, Elia, Andrea, Mucio, Ines, de Lucia, Claudio, Lucchese, Anna Maria, Gao, Erhe, Ferrara, Nicola, Rapacciuolo, Antonio, Paolocci, Nazareno, Rengo, Giuseppe, Koch, Walter J., Cannavo, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079799/
https://www.ncbi.nlm.nih.gov/pubmed/35540100
http://dx.doi.org/10.1016/j.jacbts.2022.01.001

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