PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension

The authors show that increased poly(adenosine diphosphate–ribose) polymerase 1 (PARP1) and pyruvate kinase muscle isozyme 2 (PKM2) expression is a common feature of a decompensated right ventricle in patients with pulmonary arterial hypertension and animal models. The authors find in vitro that ove...

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Detalles Bibliográficos
Autores principales: Shimauchi, Tsukasa, Boucherat, Olivier, Yokokawa, Tetsuro, Grobs, Yann, Wu, WenHui, Orcholski, Mark, Martineau, Sandra, Omura, Junichi, Tremblay, Eve, Shimauchi, Kana, Nadeau, Valérie, Breuils-Bonnet, Sandra, Paulin, Roxane, Potus, François, Provencher, Steeve, Bonnet, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079853/
https://www.ncbi.nlm.nih.gov/pubmed/35540097
http://dx.doi.org/10.1016/j.jacbts.2022.01.005

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