Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern

We conducted preclinical studies in mice using a yeast-produced SARS-CoV-2 RBD subunit vaccine candidate formulated with aluminum hydroxide (alum) and CpG deoxynucleotides. This formulation is equivalent to the Corbevax(TM) vaccine that recently received emergency use authorization by the Drugs Cont...

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Detalles Bibliográficos
Autores principales: Pollet, Jeroen, Strych, Ulrich, Chen, Wen-Hsiang, Versteeg, Leroy, Keegan, Brian, Zhan, Bin, Wei, Junfei, Liu, Zhuyun, Lee, Jungsoon, Kundu, Rahki, Adhikari, Rakesh, Poveda, Cristina, Jose Villar, Maria, Rani Thimmiraju, Syamala, Lopez, Brianna, Gillespie, Portia M., Ronca, Shannon, Kimata, Jason T., Reers, Martin, Paradkar, Vikram, Hotez, Peter J., Elena Bottazzi, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080055/
https://www.ncbi.nlm.nih.gov/pubmed/35568591
http://dx.doi.org/10.1016/j.vaccine.2022.05.007

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