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Association between annual change in FEV(1) and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation. The decline in forced expiratory volume in one second (FEV(1)) is considered to be one of the most important outcome measures for evaluating disease progression. Howev...

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Autores principales: Sugawara, Hiroyuki, Saito, Atsushi, Yokoyama, Saori, Tsunematsu, Kazunori, Chiba, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080138/
https://www.ncbi.nlm.nih.gov/pubmed/35527263
http://dx.doi.org/10.1186/s12890-022-01980-6
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author Sugawara, Hiroyuki
Saito, Atsushi
Yokoyama, Saori
Tsunematsu, Kazunori
Chiba, Hirofumi
author_facet Sugawara, Hiroyuki
Saito, Atsushi
Yokoyama, Saori
Tsunematsu, Kazunori
Chiba, Hirofumi
author_sort Sugawara, Hiroyuki
collection PubMed
description BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation. The decline in forced expiratory volume in one second (FEV(1)) is considered to be one of the most important outcome measures for evaluating disease progression. However, the only intervention proven to improve COPD prognosis is smoking cessation. This study therefore investigated the factors associated with annual FEV(1) decline in COPD. METHODS: This retrospective study followed up 65 patients treated for COPD for 5 years: 13 current smokers and 52 former smokers, 25 with pneumonia, 24 with asthma, 18 with cancer, and 17 with cardiovascular disease. The patients were divided into groups based on clinical cutoff parameters of the impulse oscillometry system (IOS): 11 high and 54 low R5, 8 high and 57 low R20, 21 high and 44 low R5–R20, 26 high and 39 low X5, 38 high and 27 low Fres, and 36 high and 29 low AX. We investigated whether the decline in FEV(1) was associated with comorbidities and IOS parameters. RESULTS: The annual change in FEV(1) over 5 years was significantly affected by smoking status (current − 66.2 mL/year vs. former − 5.7 mL/year, p < 0.01), pneumonia (with − 31.5 mL/year vs. without − 8.9 mL/year, p < 0.05), asthma (with − 30.2 mL/year vs. − 10.8 mL/year, p < 0.01), but not by cancer and cardiovascular disease. In the groups defined by IOS results, only the high AX group had significantly more annual decline in FEV(1) and %FEV(1) than the low AX group (− 22.1 vs. − 12.8, p < 0.05 and − 0.20 vs. 0.40, p < 0.05, respectively). CONCLUSIONS: Continuing smoking as well as complications in pneumonia and asthma would be risk factors for the progression of COPD. AX might be a suitable parameter to predict the prognosis of patients with COPD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-01980-6.
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spelling pubmed-90801382022-05-09 Association between annual change in FEV(1) and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease Sugawara, Hiroyuki Saito, Atsushi Yokoyama, Saori Tsunematsu, Kazunori Chiba, Hirofumi BMC Pulm Med Research BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation. The decline in forced expiratory volume in one second (FEV(1)) is considered to be one of the most important outcome measures for evaluating disease progression. However, the only intervention proven to improve COPD prognosis is smoking cessation. This study therefore investigated the factors associated with annual FEV(1) decline in COPD. METHODS: This retrospective study followed up 65 patients treated for COPD for 5 years: 13 current smokers and 52 former smokers, 25 with pneumonia, 24 with asthma, 18 with cancer, and 17 with cardiovascular disease. The patients were divided into groups based on clinical cutoff parameters of the impulse oscillometry system (IOS): 11 high and 54 low R5, 8 high and 57 low R20, 21 high and 44 low R5–R20, 26 high and 39 low X5, 38 high and 27 low Fres, and 36 high and 29 low AX. We investigated whether the decline in FEV(1) was associated with comorbidities and IOS parameters. RESULTS: The annual change in FEV(1) over 5 years was significantly affected by smoking status (current − 66.2 mL/year vs. former − 5.7 mL/year, p < 0.01), pneumonia (with − 31.5 mL/year vs. without − 8.9 mL/year, p < 0.05), asthma (with − 30.2 mL/year vs. − 10.8 mL/year, p < 0.01), but not by cancer and cardiovascular disease. In the groups defined by IOS results, only the high AX group had significantly more annual decline in FEV(1) and %FEV(1) than the low AX group (− 22.1 vs. − 12.8, p < 0.05 and − 0.20 vs. 0.40, p < 0.05, respectively). CONCLUSIONS: Continuing smoking as well as complications in pneumonia and asthma would be risk factors for the progression of COPD. AX might be a suitable parameter to predict the prognosis of patients with COPD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-01980-6. BioMed Central 2022-05-08 /pmc/articles/PMC9080138/ /pubmed/35527263 http://dx.doi.org/10.1186/s12890-022-01980-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Sugawara, Hiroyuki
Saito, Atsushi
Yokoyama, Saori
Tsunematsu, Kazunori
Chiba, Hirofumi
Association between annual change in FEV(1) and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease
title Association between annual change in FEV(1) and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease
title_full Association between annual change in FEV(1) and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease
title_fullStr Association between annual change in FEV(1) and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease
title_full_unstemmed Association between annual change in FEV(1) and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease
title_short Association between annual change in FEV(1) and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease
title_sort association between annual change in fev(1) and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080138/
https://www.ncbi.nlm.nih.gov/pubmed/35527263
http://dx.doi.org/10.1186/s12890-022-01980-6
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