Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia–reperfusion injure by restoring CPT1A mediated fatty acid oxidation

BACKGROUND: Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellular vesicles (MSC-EVs) on various diseases, but it is not clear whether they can better im...

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Detalles Bibliográficos
Autores principales: Gao, Zhumei, Zhang, Chuyue, Peng, Fei, Chen, Qianqian, Zhao, Yinghua, Chen, Liangmei, Wang, Xu, Chen, Xiangmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080148/
https://www.ncbi.nlm.nih.gov/pubmed/35526054
http://dx.doi.org/10.1186/s13287-022-02861-9

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