AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology

BACKGROUND: Changes in the expression and activity of the AKT oncogene play an important role in psychiatric disease. We present translational data assessing the role of AKT in psychiatric symptoms. METHODS: (1) We assessed the protein activity of an AKT3 mutant harboring a PH domain mutation (Q60H)...

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Detalles Bibliográficos
Autores principales: Tsimberidou, Apostolia-Maria, Skliris, Antonis, Valentine, Alan, Shaw, Jamie, Hering, Ursula, Vo, Henry Hiep, Chan, Tung On, Armen, Roger S., Cottrell, Jeffrey R., Pan, Jen Q., Tsichlis, Philip N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080159/
https://www.ncbi.nlm.nih.gov/pubmed/35525984
http://dx.doi.org/10.1186/s13578-022-00793-8

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