ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues

An eco-friendly acetylcholine iodide–ethylene glycol (ACI/EG) deep eutectic mixture mediated green protocol has been developed for the synthesis of hitherto unexplored multi-functionalized linear tricyclic spiropyrrolo[1,2-b]isoquinoline analogues. The effects of the synthesized compounds on the ost...

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Autores principales: Periyasami, Govindasami, Arumugam, Natarajan, Rahaman, Mostafizur, Kumar, Raju Suresh, Manikandan, Muthurangan, Alfayez, Musaad A., Premnath, Dhanaraj, Aldalbahi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080264/
https://www.ncbi.nlm.nih.gov/pubmed/35542235
http://dx.doi.org/10.1039/c8ra00646f
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author Periyasami, Govindasami
Arumugam, Natarajan
Rahaman, Mostafizur
Kumar, Raju Suresh
Manikandan, Muthurangan
Alfayez, Musaad A.
Premnath, Dhanaraj
Aldalbahi, Ali
author_facet Periyasami, Govindasami
Arumugam, Natarajan
Rahaman, Mostafizur
Kumar, Raju Suresh
Manikandan, Muthurangan
Alfayez, Musaad A.
Premnath, Dhanaraj
Aldalbahi, Ali
author_sort Periyasami, Govindasami
collection PubMed
description An eco-friendly acetylcholine iodide–ethylene glycol (ACI/EG) deep eutectic mixture mediated green protocol has been developed for the synthesis of hitherto unexplored multi-functionalized linear tricyclic spiropyrrolo[1,2-b]isoquinoline analogues. The effects of the synthesized compounds on the osteoblast differentiation of hBMSC-TERT cell lines were investigated and promising results were observed with significant IC(50) values. In addition, molecular modeling simulations were also performed with the 3D structure of BMP-2 to reveal binding interactions and orientations of highly potent spiropyrrolo[1,2-b]isoquinoline analogues.
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spelling pubmed-90802642022-05-09 ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues Periyasami, Govindasami Arumugam, Natarajan Rahaman, Mostafizur Kumar, Raju Suresh Manikandan, Muthurangan Alfayez, Musaad A. Premnath, Dhanaraj Aldalbahi, Ali RSC Adv Chemistry An eco-friendly acetylcholine iodide–ethylene glycol (ACI/EG) deep eutectic mixture mediated green protocol has been developed for the synthesis of hitherto unexplored multi-functionalized linear tricyclic spiropyrrolo[1,2-b]isoquinoline analogues. The effects of the synthesized compounds on the osteoblast differentiation of hBMSC-TERT cell lines were investigated and promising results were observed with significant IC(50) values. In addition, molecular modeling simulations were also performed with the 3D structure of BMP-2 to reveal binding interactions and orientations of highly potent spiropyrrolo[1,2-b]isoquinoline analogues. The Royal Society of Chemistry 2018-05-02 /pmc/articles/PMC9080264/ /pubmed/35542235 http://dx.doi.org/10.1039/c8ra00646f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Periyasami, Govindasami
Arumugam, Natarajan
Rahaman, Mostafizur
Kumar, Raju Suresh
Manikandan, Muthurangan
Alfayez, Musaad A.
Premnath, Dhanaraj
Aldalbahi, Ali
ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues
title ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues
title_full ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues
title_fullStr ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues
title_full_unstemmed ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues
title_short ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues
title_sort aci/eg eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080264/
https://www.ncbi.nlm.nih.gov/pubmed/35542235
http://dx.doi.org/10.1039/c8ra00646f
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