Cargando…

LC-MS based cell metabolic profiling of tumor cells: a new predictive method for research on the mechanism of action of anticancer candidates

In the process of anticancer drug development, research on the mechanism of action remains a major obstacle. In the present study, a cell metabolic profiling based discriminatory model was designed to give general direction on anticancer candidate mechanisms. Firstly, ultra-performance liquid chroma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Hua, Hu, Jia-hui, Liu, Cui-chai, Liu, Min, Liu, Zheng, Sun, Li-xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080298/ https://www.ncbi.nlm.nih.gov/pubmed/35540548 http://dx.doi.org/10.1039/c8ra00242h

Ejemplares similares

Reactive intermediates in copanlisib metabolism identified by LC-MS/MS: phase I metabolic profiling
por: AlRabiah, Haitham, et al.
Publicado: (2019)

Monitoring diacylglycerols in biofluids by non-isotopically paired charge derivatization combined with LC-MS/MS
por: Liu, Yang-Dan, et al.
Publicado: (2022)

Comparison of Different Labeling Techniques for the LC-MS Profiling of Human Milk Oligosaccharides
por: Lang, Yinzhi, et al.
Publicado: (2021)

Metabolic characterisation of Magnetospirillum gryphiswaldense MSR-1 using LC-MS-based metabolite profiling
por: Abdelrazig, Salah, et al.
Publicado: (2020)

LC-MS/MS Based Metabolomics Reveal Candidate Biomarkers and Metabolic Changes in Different Buffalo Species
por: Shi, Wen, et al.
Publicado: (2021)

Investigation of the metabolic stability of olmutinib by validated LC-MS/MS: quantification in human plasma
por: Attwa, Mohamed W., et al.
Publicado: (2018)

HAMA: a multiplexed LC-MS/MS assay for specificity profiling of adenylate-forming enzymes
por: Stanišić, Aleksa, et al.
Publicado: (2019)

Identification of reactive intermediate formation and bioactivation pathways in Abemaciclib metabolism by LC–MS/MS: in vitro metabolic investigation
por: Kadi, Adnan A., et al.
Publicado: (2019)

Simultaneous Determination of RDX and HMX in Rat Plasma by LC-MS/MS and its Applications
por: Zhang, Xi, et al.
Publicado: (2022)

LC-ESI-MS/MS reveals the formation of reactive intermediates in brigatinib metabolism: elucidation of bioactivation pathways
por: Kadi, Adnan A., et al.
Publicado: (2018)

Recent Progress in FD-LC-MS/MS Proteomics Method
por: Kobayashi, Hiroshi, et al.
Publicado: (2021)

Trace Level Quantification of 4-Methyl-1-nitrosopiperazin in Rifampicin Capsules by LC-MS/MS
por: Tao, Xiaosha, et al.
Publicado: (2022)

Discrimination of sepsis stage metabolic profiles with an LC/MS-MS-based metabolomics approach
por: Su, Longxiang, et al.
Publicado: (2014)

Characterization of reactive intermediates formation in dacomitinib metabolism and bioactivation pathways elucidation by LC-MS/MS: in vitro phase I metabolic investigation
por: Attwa, Mohamed W., et al.
Publicado: (2018)

Sapitinib: reactive intermediates and bioactivation pathways characterized by LC-MS/MS
por: Attwa, Mohamed W., et al.
Publicado: (2019)

A validated LC-MS/MS analytical method for the quantification of pemigatinib: metabolic stability evaluation in human liver microsomes
por: Attwa, Mohamed W., et al.
Publicado: (2022)

Global metabolomic profiling of trastuzumab resistant gastric cancer cells reveals major metabolic pathways and metabolic signatures based on UHPLC-Q exactive-MS/MS
por: Liu, Wenhu, et al.
Publicado: (2019)

Elucidating organ-specific metabolic toxicity chemistry from electrochemiluminescent enzyme/DNA arrays and bioreactor bead-LC-MS/MS
por: Wasalathanthri, Dhanuka P., et al.
Publicado: (2015)

Data to support a simultaneous testosterone and estradiol assay in serum by LC-MS/MS
por: Schofield, Ryan C., et al.
Publicado: (2018)

Data in support for the measurement of heparan sulfate and dermatan sulfate by LC–MS/MS analysis
por: Forni, Giulia, et al.
Publicado: (2018)

A matching algorithm with isotope distribution pattern in LC-MS based on support vector machine (SVM) learning model
por: Cui, Jian, et al.
Publicado: (2019)

Comparative antisickling and antioxidant activities of Pseudobombax ellipticum cultivars in relation to their metabolite profiling using LC/MS
por: Mohamed, Ahmed S., et al.
Publicado: (2023)

Simultaneous quantification of apolipoproteins A-I, E, and J in human plasma by LC-MS/MS for clinical application to diabetes mellitus complicated with cardiovascular disease
por: Li, Pengfei, et al.
Publicado: (2022)

A highly sensitive LC-MS/MS method to determine novel Bruton's tyrosine kinase inhibitor spebrutinib: application to metabolic stability evaluation
por: Abdelhameed, Ali S., et al.
Publicado: (2019)

Ginsenosides analysis of New Zealand–grown forest Panax ginseng by LC-QTOF-MS/MS
por: Chen, Wei, et al.
Publicado: (2020)

Protein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS
por: Geib, Timon, et al.
Publicado: (2021)

“Notame”: Workflow for Non-Targeted LC–MS Metabolic Profiling
por: Klåvus, Anton, et al.
Publicado: (2020)

Simultaneous Quantitation of Clevidipine and Its Active Metabolite H152/81 in Human Whole Blood by LC-MS/MS: Application to Bioequivalence Study
por: Li, Pengfei, et al.
Publicado: (2022)

Evaluation of LC-MS and LC×LC-MS in analysis of zebrafish embryo samples for comprehensive lipid profiling
por: Xu, Mengmeng, et al.
Publicado: (2020)

LC-MS/MS-Based Serum Protein Profiling for Identification of Candidate Biomarkers in Pakistani Rheumatoid Arthritis Patients
por: Jahangir, Sidrah, et al.
Publicado: (2022)

Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites
por: Attwa, Mohamed W., et al.
Publicado: (2020)

Quantitative iTRAQ LC-MS/MS reveals muscular proteome profiles of deep pressure ulcers
por: Liu, Zan, et al.
Publicado: (2020)

A novel LC-MS/MS method combined with derivatization for simultaneous quantification of vitamin D metabolites in human serum with diabetes as well as hyperlipidemia
por: Wang, Xiaodi, et al.
Publicado: (2023)

Quantification of clofarabine in urine and plasma by LC-MS/MS: suitable for PK study and TDM in pediatric patients with relapsed or refractory ALL
por: Zhang, Xi, et al.
Publicado: (2022)

LC-MS-based plasma metabolomics reveals metabolic variations in ovariectomy-induced osteoporosis in female Wistar rats
por: Hu, Yan, et al.
Publicado: (2018)

Coupling functionalized cobalt ferrite nanoparticle enrichment with online LC/MS/MS for top-down phosphoproteomics
por: Chen, Bifan, et al.
Publicado: (2017)

Rapid SPE – LC MS/MS analysis for atrazine, its by-products, simazine and S metolachlor in groundwater samples
por: Blanchoud, Hélène, et al.
Publicado: (2020)

Exposure to Mycotoxin-Mixtures via Breast Milk: An Ultra-Sensitive LC-MS/MS Biomonitoring Approach
por: Braun, Dominik, et al.
Publicado: (2020)

Identification of proteins in housefly (Musca domestica) larvae powder by LC-MS/MS and their potential medical relevance
por: Jiao, Mengya, et al.
Publicado: (2019)

Hypolipidemic effects of protein hydrolysates from Trachinotus ovatus and identification of peptides implied in bile acid-binding activity using LC-ESI-Q-TOF-MS/MS
por: Wan, Peng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_f8h1k2ch4eq4f4m91k8vlolf1r