Supramolecular hydrogels encapsulating bioengineered mesenchymal stem cells for ischemic therapy

We developed supramolecular hyaluronate (HA) hydrogels to encapsulate genetically engineered mesenchymal stem cells (MSCs) for the treatment of limb ischemia. In vivo angiogenic factors could be produced stably by the bioengineered MSCs (BMSCs) within the supramolecular hydrogels showing effective v...

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Detalles Bibliográficos
Autores principales: Hwang, Byung Woo, Kim, Young-Eun, Kim, Mungu, Han, Seulgi, Bok, Seoyeon, Park, Kyeng Min, Shrinidhi, Annadka, Kim, Ki Su, Ahn, G-One, Hahn, Sei Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080606/
https://www.ncbi.nlm.nih.gov/pubmed/35539688
http://dx.doi.org/10.1039/c8ra00464a
Descripción
Sumario:We developed supramolecular hyaluronate (HA) hydrogels to encapsulate genetically engineered mesenchymal stem cells (MSCs) for the treatment of limb ischemia. In vivo angiogenic factors could be produced stably by the bioengineered MSCs (BMSCs) within the supramolecular hydrogels showing effective vascular repair and enhanced blood perfusion.

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