GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts

BACKGROUND: Solanum khasianum is an important medicinal herb of the Solanaceae family. The present study was focused to determine the bioactive compounds in S. khasianum leaf and root extract by GC–MS analysis and their antibacterial activity by agar well diffusion method. RESULTS: Sixteen bioactive...

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Autores principales: Chirumamilla, Pavani, Dharavath, Sunitha Bai, Taduri, Shasthree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080643/
https://www.ncbi.nlm.nih.gov/pubmed/35571364
http://dx.doi.org/10.1186/s42269-022-00818-9
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author Chirumamilla, Pavani
Dharavath, Sunitha Bai
Taduri, Shasthree
author_facet Chirumamilla, Pavani
Dharavath, Sunitha Bai
Taduri, Shasthree
author_sort Chirumamilla, Pavani
collection PubMed
description BACKGROUND: Solanum khasianum is an important medicinal herb of the Solanaceae family. The present study was focused to determine the bioactive compounds in S. khasianum leaf and root extract by GC–MS analysis and their antibacterial activity by agar well diffusion method. RESULTS: Sixteen bioactive compounds were detected in leaf extract and thirty-two compounds in root methanolic extract by GC–MS. The major potent compounds identified in leaf and root extracts were heptadecane 9-hexyl (43.65%) and stigmasterol (23.18%). The root extract showed increased antibacterial activity than leaf extract. CONCLUSION: These extracts possessed significant antibacterial activity against the tested bacterial isolates in dose-dependent manner. This study provides the phytoconstituents, antibacterial property and scientific evidence for the traditional claim and use of S. khasianum.
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spelling pubmed-90806432022-05-09 GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts Chirumamilla, Pavani Dharavath, Sunitha Bai Taduri, Shasthree Bull Natl Res Cent Research BACKGROUND: Solanum khasianum is an important medicinal herb of the Solanaceae family. The present study was focused to determine the bioactive compounds in S. khasianum leaf and root extract by GC–MS analysis and their antibacterial activity by agar well diffusion method. RESULTS: Sixteen bioactive compounds were detected in leaf extract and thirty-two compounds in root methanolic extract by GC–MS. The major potent compounds identified in leaf and root extracts were heptadecane 9-hexyl (43.65%) and stigmasterol (23.18%). The root extract showed increased antibacterial activity than leaf extract. CONCLUSION: These extracts possessed significant antibacterial activity against the tested bacterial isolates in dose-dependent manner. This study provides the phytoconstituents, antibacterial property and scientific evidence for the traditional claim and use of S. khasianum. Springer Berlin Heidelberg 2022-05-08 2022 /pmc/articles/PMC9080643/ /pubmed/35571364 http://dx.doi.org/10.1186/s42269-022-00818-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Chirumamilla, Pavani
Dharavath, Sunitha Bai
Taduri, Shasthree
GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts
title GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts
title_full GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts
title_fullStr GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts
title_full_unstemmed GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts
title_short GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts
title_sort gc–ms profiling and antibacterial activity of solanum khasianum leaf and root extracts
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080643/
https://www.ncbi.nlm.nih.gov/pubmed/35571364
http://dx.doi.org/10.1186/s42269-022-00818-9
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