Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo

Based on N-cyclobutylaminoluciferin (cybLuc), a set of high and efficient caged bioluminescent derivatives (Clucs) as firefly luciferase pro-substrates has been developed herein. After careful examination, these molecules exhibited low cytotoxicity and prolonged bioluminescence imaging up to 6 h in...

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Autores principales: Zhang, Chaochao, Yuan, Mingliang, Han, Guangxi, Gao, Yuqi, Tang, Chunchao, Li, Xiang, Du, Lupei, Li, Minyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080648/
https://www.ncbi.nlm.nih.gov/pubmed/35540985
http://dx.doi.org/10.1039/c8ra02312c
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author Zhang, Chaochao
Yuan, Mingliang
Han, Guangxi
Gao, Yuqi
Tang, Chunchao
Li, Xiang
Du, Lupei
Li, Minyong
author_facet Zhang, Chaochao
Yuan, Mingliang
Han, Guangxi
Gao, Yuqi
Tang, Chunchao
Li, Xiang
Du, Lupei
Li, Minyong
author_sort Zhang, Chaochao
collection PubMed
description Based on N-cyclobutylaminoluciferin (cybLuc), a set of high and efficient caged bioluminescent derivatives (Clucs) as firefly luciferase pro-substrates has been developed herein. After careful examination, these molecules exhibited low cytotoxicity and prolonged bioluminescence imaging up to 6 h in vitro and in vivo. Importantly, these caged luciferin derivatives have the potential to serve as long-term tracking tools to explore some biological process by using bioluminescent imaging.
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spelling pubmed-90806482022-05-09 Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo Zhang, Chaochao Yuan, Mingliang Han, Guangxi Gao, Yuqi Tang, Chunchao Li, Xiang Du, Lupei Li, Minyong RSC Adv Chemistry Based on N-cyclobutylaminoluciferin (cybLuc), a set of high and efficient caged bioluminescent derivatives (Clucs) as firefly luciferase pro-substrates has been developed herein. After careful examination, these molecules exhibited low cytotoxicity and prolonged bioluminescence imaging up to 6 h in vitro and in vivo. Importantly, these caged luciferin derivatives have the potential to serve as long-term tracking tools to explore some biological process by using bioluminescent imaging. The Royal Society of Chemistry 2018-05-30 /pmc/articles/PMC9080648/ /pubmed/35540985 http://dx.doi.org/10.1039/c8ra02312c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Zhang, Chaochao
Yuan, Mingliang
Han, Guangxi
Gao, Yuqi
Tang, Chunchao
Li, Xiang
Du, Lupei
Li, Minyong
Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo
title Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo
title_full Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo
title_fullStr Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo
title_full_unstemmed Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo
title_short Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo
title_sort novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080648/
https://www.ncbi.nlm.nih.gov/pubmed/35540985
http://dx.doi.org/10.1039/c8ra02312c
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AT gaoyuqi novelcagedluciferinderivativescanprolongbioluminescenceimaginginvitroandinvivo
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