A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition

A Ni(ii)-catalyzed enantioselective Michael addition of 2-acetyl azarenes with β-difluoromethyl substituted nitroalkenes was successfully realized, which afforded chiral CF(2)H-containing compounds in good enantioselectivities (up to 93% ee). This protocol provides a new convenient approach to all-c...

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Detalles Bibliográficos
Autores principales: Yu, Xuan, Bai, Hui, Wang, Dong, Qin, Zhaohai, Li, Jia-Qi, Fu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080679/
https://www.ncbi.nlm.nih.gov/pubmed/35541018
http://dx.doi.org/10.1039/c8ra02853b
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author Yu, Xuan
Bai, Hui
Wang, Dong
Qin, Zhaohai
Li, Jia-Qi
Fu, Bin
author_facet Yu, Xuan
Bai, Hui
Wang, Dong
Qin, Zhaohai
Li, Jia-Qi
Fu, Bin
author_sort Yu, Xuan
collection PubMed
description A Ni(ii)-catalyzed enantioselective Michael addition of 2-acetyl azarenes with β-difluoromethyl substituted nitroalkenes was successfully realized, which afforded chiral CF(2)H-containing compounds in good enantioselectivities (up to 93% ee). This protocol provides a new convenient approach to all-carbon quaternary stereogenic centers featuring a CF(2)H group.
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spelling pubmed-90806792022-05-09 A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition Yu, Xuan Bai, Hui Wang, Dong Qin, Zhaohai Li, Jia-Qi Fu, Bin RSC Adv Chemistry A Ni(ii)-catalyzed enantioselective Michael addition of 2-acetyl azarenes with β-difluoromethyl substituted nitroalkenes was successfully realized, which afforded chiral CF(2)H-containing compounds in good enantioselectivities (up to 93% ee). This protocol provides a new convenient approach to all-carbon quaternary stereogenic centers featuring a CF(2)H group. The Royal Society of Chemistry 2018-05-25 /pmc/articles/PMC9080679/ /pubmed/35541018 http://dx.doi.org/10.1039/c8ra02853b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yu, Xuan
Bai, Hui
Wang, Dong
Qin, Zhaohai
Li, Jia-Qi
Fu, Bin
A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition
title A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition
title_full A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition
title_fullStr A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition
title_full_unstemmed A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition
title_short A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition
title_sort convenient approach to difluoromethylated all-carbon quaternary centers via ni(ii)-catalyzed enantioselective michael addition
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080679/
https://www.ncbi.nlm.nih.gov/pubmed/35541018
http://dx.doi.org/10.1039/c8ra02853b
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