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A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition
A Ni(ii)-catalyzed enantioselective Michael addition of 2-acetyl azarenes with β-difluoromethyl substituted nitroalkenes was successfully realized, which afforded chiral CF(2)H-containing compounds in good enantioselectivities (up to 93% ee). This protocol provides a new convenient approach to all-c...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080679/ https://www.ncbi.nlm.nih.gov/pubmed/35541018 http://dx.doi.org/10.1039/c8ra02853b |