Copper-catalyzed domino sequences: a new route to pyrido-fused quinazolinones from 2′-haloacetophenones and 2-aminopyridines

A new pathway to access pyrido-fused quinazolinones via a Cu(OAc)(2)-catalyzed domino sequential transformation between 2′-haloacetophenones and 2-aminopyridines was demonstrated. The solvent and base exhibited a remarkable effect on the transformation, in which the combination of DMSO and NaOAc eme...

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Detalles Bibliográficos
Autores principales: Pham, Phuc H., Doan, Son H., Vuong, Ngan T. H., Nguyen, Vu H. H., Ha, Phuong T. M., Phan, Nam T. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080829/
https://www.ncbi.nlm.nih.gov/pubmed/35541660
http://dx.doi.org/10.1039/c8ra03744b
Descripción
Sumario:A new pathway to access pyrido-fused quinazolinones via a Cu(OAc)(2)-catalyzed domino sequential transformation between 2′-haloacetophenones and 2-aminopyridines was demonstrated. The solvent and base exhibited a remarkable effect on the transformation, in which the combination of DMSO and NaOAc emerged as the best system. Cu(OAc)(2)·H(2)O was more active towards the reaction than numerous other catalysts. This methodology is new and would be complementary to previous protocols for the synthesis of pyrido-fused quinazolinones.

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