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A microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (PDMS) and polyurethane (PU) elastomeric membranes

Thin and flexible elastomeric membranes are frequently used in many microfluidic applications including microfluidic valves and organs-on-a-chip. The elastic properties of these membranes play an important role in the design of such microfluidic devices. Bulge testing, which is a common method to ch...

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Autores principales: Huang, Jen-Huang, Haffey, Kiersten, Arefin, Ayesha, Akhadov, Leyla E., Harris, Jennifer F., Iyer, Rashi, Nath, Pulak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080891/
https://www.ncbi.nlm.nih.gov/pubmed/35539930
http://dx.doi.org/10.1039/c8ra01256c
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author Huang, Jen-Huang
Haffey, Kiersten
Arefin, Ayesha
Akhadov, Leyla E.
Harris, Jennifer F.
Iyer, Rashi
Nath, Pulak
author_facet Huang, Jen-Huang
Haffey, Kiersten
Arefin, Ayesha
Akhadov, Leyla E.
Harris, Jennifer F.
Iyer, Rashi
Nath, Pulak
author_sort Huang, Jen-Huang
collection PubMed
description Thin and flexible elastomeric membranes are frequently used in many microfluidic applications including microfluidic valves and organs-on-a-chip. The elastic properties of these membranes play an important role in the design of such microfluidic devices. Bulge testing, which is a common method to characterize the elastic behavior of these membranes, involves direct observation of the changes in the bulge height in response to a range of applied pressures. Here, we report a microfluidic approach to measure the bulging height of elastic membranes to replace direct observation of the bulge height under a microscope. Bulging height is measured by tracking the displacement of a fluid inside a microfluidic channel, where the fluid in the channel was designed to be directly in contact with the elastomeric membrane. Polydimethylsiloxane (PDMS) and polyurethane (PU) membranes with thickness 12–35 μm were fabricated by spin coating for bulge testing using both direct optical observation and the microfluidic method. Bulging height determined from the optical method was subject to interpretation by the user, whereas the microfluidic approach provided a simple but sensitive method for determining the bulging height of membranes down to a few micrometers. This work validates the proof of principle that uses microfluidics to accurately measure bulging height in conventional bulge testing for polydimethylsiloxane (PDMS) and polyurethane (PU)eElastomeric membranes.
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spelling pubmed-90808912022-05-09 A microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (PDMS) and polyurethane (PU) elastomeric membranes Huang, Jen-Huang Haffey, Kiersten Arefin, Ayesha Akhadov, Leyla E. Harris, Jennifer F. Iyer, Rashi Nath, Pulak RSC Adv Chemistry Thin and flexible elastomeric membranes are frequently used in many microfluidic applications including microfluidic valves and organs-on-a-chip. The elastic properties of these membranes play an important role in the design of such microfluidic devices. Bulge testing, which is a common method to characterize the elastic behavior of these membranes, involves direct observation of the changes in the bulge height in response to a range of applied pressures. Here, we report a microfluidic approach to measure the bulging height of elastic membranes to replace direct observation of the bulge height under a microscope. Bulging height is measured by tracking the displacement of a fluid inside a microfluidic channel, where the fluid in the channel was designed to be directly in contact with the elastomeric membrane. Polydimethylsiloxane (PDMS) and polyurethane (PU) membranes with thickness 12–35 μm were fabricated by spin coating for bulge testing using both direct optical observation and the microfluidic method. Bulging height determined from the optical method was subject to interpretation by the user, whereas the microfluidic approach provided a simple but sensitive method for determining the bulging height of membranes down to a few micrometers. This work validates the proof of principle that uses microfluidics to accurately measure bulging height in conventional bulge testing for polydimethylsiloxane (PDMS) and polyurethane (PU)eElastomeric membranes. The Royal Society of Chemistry 2018-06-08 /pmc/articles/PMC9080891/ /pubmed/35539930 http://dx.doi.org/10.1039/c8ra01256c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Huang, Jen-Huang
Haffey, Kiersten
Arefin, Ayesha
Akhadov, Leyla E.
Harris, Jennifer F.
Iyer, Rashi
Nath, Pulak
A microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (PDMS) and polyurethane (PU) elastomeric membranes
title A microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (PDMS) and polyurethane (PU) elastomeric membranes
title_full A microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (PDMS) and polyurethane (PU) elastomeric membranes
title_fullStr A microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (PDMS) and polyurethane (PU) elastomeric membranes
title_full_unstemmed A microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (PDMS) and polyurethane (PU) elastomeric membranes
title_short A microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (PDMS) and polyurethane (PU) elastomeric membranes
title_sort microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (pdms) and polyurethane (pu) elastomeric membranes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080891/
https://www.ncbi.nlm.nih.gov/pubmed/35539930
http://dx.doi.org/10.1039/c8ra01256c
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