Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA the...

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Autores principales: Ma, Luoyang, Zheng, Xiaoyan, Lin, Rui, Sun, Antonia RuJia, Song, Jintong, Ye, Zhiqiang, Liang, Dahong, Zhang, Min, Tian, Jia, Zhou, Xin, Cui, Liao, Liu, Yuyu, Liu, Yanzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081192/
https://www.ncbi.nlm.nih.gov/pubmed/35547865
http://dx.doi.org/10.2147/DDDT.S357386
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author Ma, Luoyang
Zheng, Xiaoyan
Lin, Rui
Sun, Antonia RuJia
Song, Jintong
Ye, Zhiqiang
Liang, Dahong
Zhang, Min
Tian, Jia
Zhou, Xin
Cui, Liao
Liu, Yuyu
Liu, Yanzhi
author_facet Ma, Luoyang
Zheng, Xiaoyan
Lin, Rui
Sun, Antonia RuJia
Song, Jintong
Ye, Zhiqiang
Liang, Dahong
Zhang, Min
Tian, Jia
Zhou, Xin
Cui, Liao
Liu, Yuyu
Liu, Yanzhi
author_sort Ma, Luoyang
collection PubMed
description Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the continuous advancement in OA mechanism research, new drugs targeting specific cell/signaling pathways in OA are rapidly evolving and effective drug delivery is critical for treating OA. In this review, recent advances in various IA drug-delivery systems for OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are summarized and analyzed based on current publications.
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spelling pubmed-90811922022-05-10 Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems Ma, Luoyang Zheng, Xiaoyan Lin, Rui Sun, Antonia RuJia Song, Jintong Ye, Zhiqiang Liang, Dahong Zhang, Min Tian, Jia Zhou, Xin Cui, Liao Liu, Yuyu Liu, Yanzhi Drug Des Devel Ther Review Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the continuous advancement in OA mechanism research, new drugs targeting specific cell/signaling pathways in OA are rapidly evolving and effective drug delivery is critical for treating OA. In this review, recent advances in various IA drug-delivery systems for OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are summarized and analyzed based on current publications. Dove 2022-05-04 /pmc/articles/PMC9081192/ /pubmed/35547865 http://dx.doi.org/10.2147/DDDT.S357386 Text en © 2022 Ma et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Ma, Luoyang
Zheng, Xiaoyan
Lin, Rui
Sun, Antonia RuJia
Song, Jintong
Ye, Zhiqiang
Liang, Dahong
Zhang, Min
Tian, Jia
Zhou, Xin
Cui, Liao
Liu, Yuyu
Liu, Yanzhi
Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
title Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
title_full Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
title_fullStr Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
title_full_unstemmed Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
title_short Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
title_sort knee osteoarthritis therapy: recent advances in intra-articular drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081192/
https://www.ncbi.nlm.nih.gov/pubmed/35547865
http://dx.doi.org/10.2147/DDDT.S357386
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