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Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis

Interactions between the immune and central nervous systems strongly influence brain health. Although the blood-brain barrier restricts this crosstalk, we now know that meningeal gateways through brain border tissues facilitate intersystem communication. Cerebrospinal fluid, which interfaces with th...

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Autores principales: Pulous, Fadi E., Cruz-Hernández, Jean C., Yang, Chongbo, Kaya, Ζeynep, Paccalet, Alexandre, Wojtkiewicz, Gregory, Capen, Diane, Brown, Dennis, Wu, Juwell W., Schloss, Maximillian J., Vinegoni, Claudio, Richter, Dmitry, Yamazoe, Masahiro, Hulsmans, Maarten, Momin, Noor, Grune, Jana, Rohde, David, McAlpine, Cameron S., Panizzi, Peter, Weissleder, Ralph, Kim, Dong-Eog, Swirski, Filip K., Lin, Charles P., Moskowitz, Michael A., Nahrendorf, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081225/
https://www.ncbi.nlm.nih.gov/pubmed/35501382
http://dx.doi.org/10.1038/s41593-022-01060-2
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author Pulous, Fadi E.
Cruz-Hernández, Jean C.
Yang, Chongbo
Kaya, Ζeynep
Paccalet, Alexandre
Wojtkiewicz, Gregory
Capen, Diane
Brown, Dennis
Wu, Juwell W.
Schloss, Maximillian J.
Vinegoni, Claudio
Richter, Dmitry
Yamazoe, Masahiro
Hulsmans, Maarten
Momin, Noor
Grune, Jana
Rohde, David
McAlpine, Cameron S.
Panizzi, Peter
Weissleder, Ralph
Kim, Dong-Eog
Swirski, Filip K.
Lin, Charles P.
Moskowitz, Michael A.
Nahrendorf, Matthias
author_facet Pulous, Fadi E.
Cruz-Hernández, Jean C.
Yang, Chongbo
Kaya, Ζeynep
Paccalet, Alexandre
Wojtkiewicz, Gregory
Capen, Diane
Brown, Dennis
Wu, Juwell W.
Schloss, Maximillian J.
Vinegoni, Claudio
Richter, Dmitry
Yamazoe, Masahiro
Hulsmans, Maarten
Momin, Noor
Grune, Jana
Rohde, David
McAlpine, Cameron S.
Panizzi, Peter
Weissleder, Ralph
Kim, Dong-Eog
Swirski, Filip K.
Lin, Charles P.
Moskowitz, Michael A.
Nahrendorf, Matthias
author_sort Pulous, Fadi E.
collection PubMed
description Interactions between the immune and central nervous systems strongly influence brain health. Although the blood-brain barrier restricts this crosstalk, we now know that meningeal gateways through brain border tissues facilitate intersystem communication. Cerebrospinal fluid, which interfaces with the glymphatic system and thereby drains the brain’s interstitial and perivascular spaces, facilitates outward signaling beyond the blood-brain barrier. Here, we report that cerebrospinal fluid can exit into the skull bone marrow. Fluorescent tracers injected into the cisterna magna of mice migrate along perivascular spaces of dural blood vessels and then travel through hundreds of sub-millimeter skull channels into the calvarial marrow. During meningitis, bacteria hijack this route to invade the skull’s hematopoietic niches and initiate cranial hematopoiesis ahead of remote tibial sites. Because skull channels also directly provide leukocytes to meninges, the privileged sampling of brain-derived danger signals in cerebrospinal fluid by regional marrow may have broad implications for inflammatory neurological disorders.
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spelling pubmed-90812252022-11-02 Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis Pulous, Fadi E. Cruz-Hernández, Jean C. Yang, Chongbo Kaya, Ζeynep Paccalet, Alexandre Wojtkiewicz, Gregory Capen, Diane Brown, Dennis Wu, Juwell W. Schloss, Maximillian J. Vinegoni, Claudio Richter, Dmitry Yamazoe, Masahiro Hulsmans, Maarten Momin, Noor Grune, Jana Rohde, David McAlpine, Cameron S. Panizzi, Peter Weissleder, Ralph Kim, Dong-Eog Swirski, Filip K. Lin, Charles P. Moskowitz, Michael A. Nahrendorf, Matthias Nat Neurosci Article Interactions between the immune and central nervous systems strongly influence brain health. Although the blood-brain barrier restricts this crosstalk, we now know that meningeal gateways through brain border tissues facilitate intersystem communication. Cerebrospinal fluid, which interfaces with the glymphatic system and thereby drains the brain’s interstitial and perivascular spaces, facilitates outward signaling beyond the blood-brain barrier. Here, we report that cerebrospinal fluid can exit into the skull bone marrow. Fluorescent tracers injected into the cisterna magna of mice migrate along perivascular spaces of dural blood vessels and then travel through hundreds of sub-millimeter skull channels into the calvarial marrow. During meningitis, bacteria hijack this route to invade the skull’s hematopoietic niches and initiate cranial hematopoiesis ahead of remote tibial sites. Because skull channels also directly provide leukocytes to meninges, the privileged sampling of brain-derived danger signals in cerebrospinal fluid by regional marrow may have broad implications for inflammatory neurological disorders. 2022-05 2022-05-02 /pmc/articles/PMC9081225/ /pubmed/35501382 http://dx.doi.org/10.1038/s41593-022-01060-2 Text en <p>Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: <uri xlink:href="https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms"></p>
spellingShingle Article
Pulous, Fadi E.
Cruz-Hernández, Jean C.
Yang, Chongbo
Kaya, Ζeynep
Paccalet, Alexandre
Wojtkiewicz, Gregory
Capen, Diane
Brown, Dennis
Wu, Juwell W.
Schloss, Maximillian J.
Vinegoni, Claudio
Richter, Dmitry
Yamazoe, Masahiro
Hulsmans, Maarten
Momin, Noor
Grune, Jana
Rohde, David
McAlpine, Cameron S.
Panizzi, Peter
Weissleder, Ralph
Kim, Dong-Eog
Swirski, Filip K.
Lin, Charles P.
Moskowitz, Michael A.
Nahrendorf, Matthias
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
title Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
title_full Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
title_fullStr Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
title_full_unstemmed Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
title_short Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
title_sort cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081225/
https://www.ncbi.nlm.nih.gov/pubmed/35501382
http://dx.doi.org/10.1038/s41593-022-01060-2
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