B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
BACKGROUND: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell no...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081255/ https://www.ncbi.nlm.nih.gov/pubmed/35244686 http://dx.doi.org/10.1158/1055-9965.EPI-21-0875 |
_version_ | 1784702949716393984 |
---|---|
author | Wang, Sophia S. Vajdic, Claire M. Linet, Martha S. Slager, Susan L. Voutsinas, Jenna Nieters, Alexandra Casabonne, Delphine Cerhan, James R. Cozen, Wendy Alarcón, Graciela Martínez-Maza, Otoniel Brown, Elizabeth E. Bracci, Paige M. Turner, Jennifer Hjalgrim, Henrik Bhatti, Parveen Zhang, Yawei Birmann, Brenda M. Flowers, Christopher R. Paltiel, Ora Holly, Elizabeth A. Kane, Eleanor Weisenburger, Dennis D. Maynadié, Marc Cocco, Pierluigi Foretova, Lenka Breen, Elizabeth Crabb Lan, Qing Brooks-Wilson, Angela De Roos, Anneclaire J. Smith, Martyn T. Roman, Eve Boffetta, Paolo Kricker, Anne Zheng, Tongzhang Skibola, Christine F. Clavel, Jacqueline Monnereau, Alain Chanock, Stephen J. Rothman, Nathaniel Benavente, Yolanda Hartge, Patricia Smedby, Karin E. |
author_facet | Wang, Sophia S. Vajdic, Claire M. Linet, Martha S. Slager, Susan L. Voutsinas, Jenna Nieters, Alexandra Casabonne, Delphine Cerhan, James R. Cozen, Wendy Alarcón, Graciela Martínez-Maza, Otoniel Brown, Elizabeth E. Bracci, Paige M. Turner, Jennifer Hjalgrim, Henrik Bhatti, Parveen Zhang, Yawei Birmann, Brenda M. Flowers, Christopher R. Paltiel, Ora Holly, Elizabeth A. Kane, Eleanor Weisenburger, Dennis D. Maynadié, Marc Cocco, Pierluigi Foretova, Lenka Breen, Elizabeth Crabb Lan, Qing Brooks-Wilson, Angela De Roos, Anneclaire J. Smith, Martyn T. Roman, Eve Boffetta, Paolo Kricker, Anne Zheng, Tongzhang Skibola, Christine F. Clavel, Jacqueline Monnereau, Alain Chanock, Stephen J. Rothman, Nathaniel Benavente, Yolanda Hartge, Patricia Smedby, Karin E. |
author_sort | Wang, Sophia S. |
collection | PubMed |
description | BACKGROUND: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non–Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. METHODS: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell–mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression. RESULTS: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR = 1.24; 95% confidence interval (CI), 1.08–1.43; T3 vs. T1: OR = 1.81; 95% CI, 1.59–2.07; P-trend (P(trend)) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell–mediated autoimmune condition and a T3 PRS [OR = 6.46 vs. no autoimmune condition and a T1 PRS, P(trend) < 0.0001, P-interaction (P(interaction)) = 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant P(interaction). CONCLUSIONS: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. IMPACT: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL. |
format | Online Article Text |
id | pubmed-9081255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for Cancer Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-90812552022-05-09 B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS Wang, Sophia S. Vajdic, Claire M. Linet, Martha S. Slager, Susan L. Voutsinas, Jenna Nieters, Alexandra Casabonne, Delphine Cerhan, James R. Cozen, Wendy Alarcón, Graciela Martínez-Maza, Otoniel Brown, Elizabeth E. Bracci, Paige M. Turner, Jennifer Hjalgrim, Henrik Bhatti, Parveen Zhang, Yawei Birmann, Brenda M. Flowers, Christopher R. Paltiel, Ora Holly, Elizabeth A. Kane, Eleanor Weisenburger, Dennis D. Maynadié, Marc Cocco, Pierluigi Foretova, Lenka Breen, Elizabeth Crabb Lan, Qing Brooks-Wilson, Angela De Roos, Anneclaire J. Smith, Martyn T. Roman, Eve Boffetta, Paolo Kricker, Anne Zheng, Tongzhang Skibola, Christine F. Clavel, Jacqueline Monnereau, Alain Chanock, Stephen J. Rothman, Nathaniel Benavente, Yolanda Hartge, Patricia Smedby, Karin E. Cancer Epidemiol Biomarkers Prev Research Articles BACKGROUND: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non–Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. METHODS: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell–mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression. RESULTS: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR = 1.24; 95% confidence interval (CI), 1.08–1.43; T3 vs. T1: OR = 1.81; 95% CI, 1.59–2.07; P-trend (P(trend)) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell–mediated autoimmune condition and a T3 PRS [OR = 6.46 vs. no autoimmune condition and a T1 PRS, P(trend) < 0.0001, P-interaction (P(interaction)) = 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant P(interaction). CONCLUSIONS: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. IMPACT: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL. American Association for Cancer Research 2022-05-04 2022-02-24 /pmc/articles/PMC9081255/ /pubmed/35244686 http://dx.doi.org/10.1158/1055-9965.EPI-21-0875 Text en ©2022 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. |
spellingShingle | Research Articles Wang, Sophia S. Vajdic, Claire M. Linet, Martha S. Slager, Susan L. Voutsinas, Jenna Nieters, Alexandra Casabonne, Delphine Cerhan, James R. Cozen, Wendy Alarcón, Graciela Martínez-Maza, Otoniel Brown, Elizabeth E. Bracci, Paige M. Turner, Jennifer Hjalgrim, Henrik Bhatti, Parveen Zhang, Yawei Birmann, Brenda M. Flowers, Christopher R. Paltiel, Ora Holly, Elizabeth A. Kane, Eleanor Weisenburger, Dennis D. Maynadié, Marc Cocco, Pierluigi Foretova, Lenka Breen, Elizabeth Crabb Lan, Qing Brooks-Wilson, Angela De Roos, Anneclaire J. Smith, Martyn T. Roman, Eve Boffetta, Paolo Kricker, Anne Zheng, Tongzhang Skibola, Christine F. Clavel, Jacqueline Monnereau, Alain Chanock, Stephen J. Rothman, Nathaniel Benavente, Yolanda Hartge, Patricia Smedby, Karin E. B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS |
title | B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS |
title_full | B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS |
title_fullStr | B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS |
title_full_unstemmed | B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS |
title_short | B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS |
title_sort | b-cell nhl subtype risk associated with autoimmune conditions and prs |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081255/ https://www.ncbi.nlm.nih.gov/pubmed/35244686 http://dx.doi.org/10.1158/1055-9965.EPI-21-0875 |
work_keys_str_mv | AT wangsophias bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT vajdicclairem bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT linetmarthas bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT slagersusanl bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT voutsinasjenna bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT nietersalexandra bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT casabonnedelphine bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT cerhanjamesr bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT cozenwendy bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT alarcongraciela bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT martinezmazaotoniel bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT brownelizabethe bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT braccipaigem bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT turnerjennifer bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT hjalgrimhenrik bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT bhattiparveen bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT zhangyawei bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT birmannbrendam bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT flowerschristopherr bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT paltielora bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT hollyelizabetha bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT kaneeleanor bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT weisenburgerdennisd bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT maynadiemarc bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT coccopierluigi bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT foretovalenka bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT breenelizabethcrabb bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT lanqing bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT brookswilsonangela bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT deroosanneclairej bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT smithmartynt bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT romaneve bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT boffettapaolo bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT krickeranne bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT zhengtongzhang bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT skibolachristinef bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT claveljacqueline bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT monnereaualain bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT chanockstephenj bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT rothmannathaniel bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT benaventeyolanda bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT hartgepatricia bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs AT smedbykarine bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs |