B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS

BACKGROUND: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell no...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Sophia S., Vajdic, Claire M., Linet, Martha S., Slager, Susan L., Voutsinas, Jenna, Nieters, Alexandra, Casabonne, Delphine, Cerhan, James R., Cozen, Wendy, Alarcón, Graciela, Martínez-Maza, Otoniel, Brown, Elizabeth E., Bracci, Paige M., Turner, Jennifer, Hjalgrim, Henrik, Bhatti, Parveen, Zhang, Yawei, Birmann, Brenda M., Flowers, Christopher R., Paltiel, Ora, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis D., Maynadié, Marc, Cocco, Pierluigi, Foretova, Lenka, Breen, Elizabeth Crabb, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J., Smith, Martyn T., Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zheng, Tongzhang, Skibola, Christine F., Clavel, Jacqueline, Monnereau, Alain, Chanock, Stephen J., Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, Smedby, Karin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081255/
https://www.ncbi.nlm.nih.gov/pubmed/35244686
http://dx.doi.org/10.1158/1055-9965.EPI-21-0875
_version_ 1784702949716393984
author Wang, Sophia S.
Vajdic, Claire M.
Linet, Martha S.
Slager, Susan L.
Voutsinas, Jenna
Nieters, Alexandra
Casabonne, Delphine
Cerhan, James R.
Cozen, Wendy
Alarcón, Graciela
Martínez-Maza, Otoniel
Brown, Elizabeth E.
Bracci, Paige M.
Turner, Jennifer
Hjalgrim, Henrik
Bhatti, Parveen
Zhang, Yawei
Birmann, Brenda M.
Flowers, Christopher R.
Paltiel, Ora
Holly, Elizabeth A.
Kane, Eleanor
Weisenburger, Dennis D.
Maynadié, Marc
Cocco, Pierluigi
Foretova, Lenka
Breen, Elizabeth Crabb
Lan, Qing
Brooks-Wilson, Angela
De Roos, Anneclaire J.
Smith, Martyn T.
Roman, Eve
Boffetta, Paolo
Kricker, Anne
Zheng, Tongzhang
Skibola, Christine F.
Clavel, Jacqueline
Monnereau, Alain
Chanock, Stephen J.
Rothman, Nathaniel
Benavente, Yolanda
Hartge, Patricia
Smedby, Karin E.
author_facet Wang, Sophia S.
Vajdic, Claire M.
Linet, Martha S.
Slager, Susan L.
Voutsinas, Jenna
Nieters, Alexandra
Casabonne, Delphine
Cerhan, James R.
Cozen, Wendy
Alarcón, Graciela
Martínez-Maza, Otoniel
Brown, Elizabeth E.
Bracci, Paige M.
Turner, Jennifer
Hjalgrim, Henrik
Bhatti, Parveen
Zhang, Yawei
Birmann, Brenda M.
Flowers, Christopher R.
Paltiel, Ora
Holly, Elizabeth A.
Kane, Eleanor
Weisenburger, Dennis D.
Maynadié, Marc
Cocco, Pierluigi
Foretova, Lenka
Breen, Elizabeth Crabb
Lan, Qing
Brooks-Wilson, Angela
De Roos, Anneclaire J.
Smith, Martyn T.
Roman, Eve
Boffetta, Paolo
Kricker, Anne
Zheng, Tongzhang
Skibola, Christine F.
Clavel, Jacqueline
Monnereau, Alain
Chanock, Stephen J.
Rothman, Nathaniel
Benavente, Yolanda
Hartge, Patricia
Smedby, Karin E.
author_sort Wang, Sophia S.
collection PubMed
description BACKGROUND: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non–Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. METHODS: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell–mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression. RESULTS: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR = 1.24; 95% confidence interval (CI), 1.08–1.43; T3 vs. T1: OR = 1.81; 95% CI, 1.59–2.07; P-trend (P(trend)) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell–mediated autoimmune condition and a T3 PRS [OR = 6.46 vs. no autoimmune condition and a T1 PRS, P(trend) < 0.0001, P-interaction (P(interaction)) = 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant P(interaction). CONCLUSIONS: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. IMPACT: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL.
format Online
Article
Text
id pubmed-9081255
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Association for Cancer Research
record_format MEDLINE/PubMed
spelling pubmed-90812552022-05-09 B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS Wang, Sophia S. Vajdic, Claire M. Linet, Martha S. Slager, Susan L. Voutsinas, Jenna Nieters, Alexandra Casabonne, Delphine Cerhan, James R. Cozen, Wendy Alarcón, Graciela Martínez-Maza, Otoniel Brown, Elizabeth E. Bracci, Paige M. Turner, Jennifer Hjalgrim, Henrik Bhatti, Parveen Zhang, Yawei Birmann, Brenda M. Flowers, Christopher R. Paltiel, Ora Holly, Elizabeth A. Kane, Eleanor Weisenburger, Dennis D. Maynadié, Marc Cocco, Pierluigi Foretova, Lenka Breen, Elizabeth Crabb Lan, Qing Brooks-Wilson, Angela De Roos, Anneclaire J. Smith, Martyn T. Roman, Eve Boffetta, Paolo Kricker, Anne Zheng, Tongzhang Skibola, Christine F. Clavel, Jacqueline Monnereau, Alain Chanock, Stephen J. Rothman, Nathaniel Benavente, Yolanda Hartge, Patricia Smedby, Karin E. Cancer Epidemiol Biomarkers Prev Research Articles BACKGROUND: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non–Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. METHODS: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell–mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression. RESULTS: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR = 1.24; 95% confidence interval (CI), 1.08–1.43; T3 vs. T1: OR = 1.81; 95% CI, 1.59–2.07; P-trend (P(trend)) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell–mediated autoimmune condition and a T3 PRS [OR = 6.46 vs. no autoimmune condition and a T1 PRS, P(trend) < 0.0001, P-interaction (P(interaction)) = 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant P(interaction). CONCLUSIONS: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. IMPACT: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL. American Association for Cancer Research 2022-05-04 2022-02-24 /pmc/articles/PMC9081255/ /pubmed/35244686 http://dx.doi.org/10.1158/1055-9965.EPI-21-0875 Text en ©2022 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
spellingShingle Research Articles
Wang, Sophia S.
Vajdic, Claire M.
Linet, Martha S.
Slager, Susan L.
Voutsinas, Jenna
Nieters, Alexandra
Casabonne, Delphine
Cerhan, James R.
Cozen, Wendy
Alarcón, Graciela
Martínez-Maza, Otoniel
Brown, Elizabeth E.
Bracci, Paige M.
Turner, Jennifer
Hjalgrim, Henrik
Bhatti, Parveen
Zhang, Yawei
Birmann, Brenda M.
Flowers, Christopher R.
Paltiel, Ora
Holly, Elizabeth A.
Kane, Eleanor
Weisenburger, Dennis D.
Maynadié, Marc
Cocco, Pierluigi
Foretova, Lenka
Breen, Elizabeth Crabb
Lan, Qing
Brooks-Wilson, Angela
De Roos, Anneclaire J.
Smith, Martyn T.
Roman, Eve
Boffetta, Paolo
Kricker, Anne
Zheng, Tongzhang
Skibola, Christine F.
Clavel, Jacqueline
Monnereau, Alain
Chanock, Stephen J.
Rothman, Nathaniel
Benavente, Yolanda
Hartge, Patricia
Smedby, Karin E.
B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
title B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
title_full B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
title_fullStr B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
title_full_unstemmed B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
title_short B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
title_sort b-cell nhl subtype risk associated with autoimmune conditions and prs
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081255/
https://www.ncbi.nlm.nih.gov/pubmed/35244686
http://dx.doi.org/10.1158/1055-9965.EPI-21-0875
work_keys_str_mv AT wangsophias bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT vajdicclairem bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT linetmarthas bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT slagersusanl bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT voutsinasjenna bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT nietersalexandra bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT casabonnedelphine bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT cerhanjamesr bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT cozenwendy bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT alarcongraciela bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT martinezmazaotoniel bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT brownelizabethe bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT braccipaigem bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT turnerjennifer bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT hjalgrimhenrik bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT bhattiparveen bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT zhangyawei bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT birmannbrendam bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT flowerschristopherr bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT paltielora bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT hollyelizabetha bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT kaneeleanor bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT weisenburgerdennisd bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT maynadiemarc bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT coccopierluigi bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT foretovalenka bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT breenelizabethcrabb bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT lanqing bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT brookswilsonangela bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT deroosanneclairej bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT smithmartynt bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT romaneve bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT boffettapaolo bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT krickeranne bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT zhengtongzhang bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT skibolachristinef bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT claveljacqueline bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT monnereaualain bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT chanockstephenj bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT rothmannathaniel bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT benaventeyolanda bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT hartgepatricia bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs
AT smedbykarine bcellnhlsubtyperiskassociatedwithautoimmuneconditionsandprs