Cargando…

Stat3 Signaling Pathway: A Future Therapeutic Target for Bone-Related Diseases

Signal transducer and activator of transcription 3 (Stat3) is activated by phosphorylation and translocated to the nucleus to participate in the transcriptional regulation of DNA. Increasing evidences point that aberrant activation or deletion of the Stat3 plays a critical role in a broad range of p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jiadong, Yin, Zhifeng, Huang, Biaotong, Xu, Ke, Su, Jiacan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081430/ https://www.ncbi.nlm.nih.gov/pubmed/35548357 http://dx.doi.org/10.3389/fphar.2022.897539

Ejemplares similares

Bone-Targeted Nanoparticle Drug Delivery System: An Emerging Strategy for Bone-Related Disease
por: Chen, Yulin, et al.
Publicado: (2022)

18β-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK–TRAF6 Interactions and NF-κB and MAPK Signaling Pathways
por: Chen, Xiao, et al.
Publicado: (2018)

Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation
por: Gao, Qianmin, et al.
Publicado: (2022)

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies
por: Rah, Bilal, et al.
Publicado: (2022)

Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway
por: Yin, Qianqian, et al.
Publicado: (2021)

STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future Prospects
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Molecular mechanisms of ferroptosis and the potential therapeutic targets of ferroptosis signaling pathways for glioblastoma
por: Zhang, Meng, et al.
Publicado: (2022)

Microenvironment-targeted strategy steers advanced bone regeneration
por: Hao, Shuyue, et al.
Publicado: (2023)

Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
por: Hua, Yaping, et al.
Publicado: (2022)

Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
por: Sudhesh Dev, Sareshma, et al.
Publicado: (2021)

Triptolide prevents bone loss via suppressing osteoclastogenesis through inhibiting PI3K‐AKT‐NFATc1 pathway
por: Cui, Jin, et al.
Publicado: (2020)

Eupalinolide J Suppresses the Growth of Triple-Negative Breast Cancer Cells via Targeting STAT3 Signaling Pathway
por: Lou, Chenghua, et al.
Publicado: (2019)

Yi Shen Juan Bi Pill Regulates the Bone Immune Microenvironment via the JAK2/STAT3 Signaling Pathway in Vitro
por: Xia, Ya, et al.
Publicado: (2021)

Inhibition of Stat3 Signaling Pathway by Natural Product Pectolinarigenin Attenuates Breast Cancer Metastasis
por: Li, Yali, et al.
Publicado: (2019)

Inhibition of the STAT3 Signaling Pathway Contributes to the Anti-Melanoma Activities of Shikonin
por: Cao, Hui-Hui, et al.
Publicado: (2020)

Butyric Acid Increases the Therapeutic Effect of EHLJ7 on Ulcerative Colitis by Inhibiting JAK2/STAT3/SOCS1 Signaling Pathway
por: Tang, Xiaonan, et al.
Publicado: (2020)

Therapeutic Potential of Triptolide in Treating Bone-Related Disorders
por: Gang, Wu, et al.
Publicado: (2022)

Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway
por: Li, Zhen, et al.
Publicado: (2022)

A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5
por: Xin, Zhi, et al.
Publicado: (2018)

Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer
por: Yu, Dehua, et al.
Publicado: (2022)

Corrigendum: A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5
por: Xin, Zhi, et al.
Publicado: (2021)

CXCL6 Promotes Renal Interstitial Fibrosis in Diabetic Nephropathy by Activating JAK/STAT3 Signaling Pathway
por: Sun, Meng-Yao, et al.
Publicado: (2019)

Pyroptosis-Related Inflammasome Pathway: A New Therapeutic Target for Diabetic Cardiomyopathy
por: Cai, Zhengyao, et al.
Publicado: (2022)

Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets
por: Wang, Haijun, et al.
Publicado: (2021)

Protein tyrosine phosphatase non-receptor type 2 as the therapeutic target of atherosclerotic diseases: past, present and future
por: Tang, Xiao-Er, et al.
Publicado: (2023)

Exosome-Laden Hydrogels: A Novel Cell-free Strategy for In-situ Bone Tissue Regeneration
por: Sun, Jinru, et al.
Publicado: (2022)

The regulation of T helper cell polarization by the diterpenoid fraction of Rhododendron molle based on the JAK/STAT signaling pathway
por: Qin, JiaXu, et al.
Publicado: (2022)

Targeting the Wnt/β-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis
por: Li, Shan-Shan, et al.
Publicado: (2021)

Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease
por: Wang, Yumin, et al.
Publicado: (2021)

Myricetin Induces Autophagy and Cell Cycle Arrest of HCC by Inhibiting MARCH1-Regulated Stat3 and p38 MAPK Signaling Pathways
por: Yang, Wei, et al.
Publicado: (2021)

The Roles of TNF Signaling Pathways in Metabolism of Bone Tumors
por: Zhou, Haiying, et al.
Publicado: (2022)

Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
por: Alam, Manzar, et al.
Publicado: (2022)

ErHuang Formula Improves Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting CXCL6/JAK/STAT3 Signaling Pathway
por: Shen, Yu-Li, et al.
Publicado: (2020)

Editorial: Ferroptosis as a novel therapeutic target for inflammation-related diseases
por: Liang, Yongyi, et al.
Publicado: (2023)

Tirbanibulin Attenuates Pulmonary Fibrosis by Modulating Src/STAT3 Signaling
por: Wang, Xin, et al.
Publicado: (2021)

Angelicin Alleviates Post-Trauma Osteoarthritis Progression by Regulating Macrophage Polarization via STAT3 Signaling Pathway
por: Tian, Zhansong, et al.
Publicado: (2021)

Targeting Nrf2-Mediated Oxidative Stress Response Signaling Pathways as New Therapeutic Strategy for Pituitary Adenomas
por: Zhan, Xianquan, et al.
Publicado: (2021)

Flavonoid Group of Smilax glabra Roxb. Regulates the Anti-Tumor Immune Response Through the STAT3/HIF-1 Signaling Pathway
por: Guo, Yingxue, et al.
Publicado: (2022)

Contribution of Janus-Kinase/Signal Transduction Activator of Transcription Pathway in the Pathogenesis of Vasculitis: A Possible Treatment Target in the Upcoming Future
por: Bursi, Roberto, et al.
Publicado: (2021)

Corrigendum: ErHuang Formula Improves Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting CXCL6/JAK/STAT3 Signaling Pathway
por: Shen, Yu-Li, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q18kj819gimmi7liekfgrsvs92