Cargando…

Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis

Coronavirus disease 2019 (COVID-19) can disrupt the gut microbiota balance, and patients usually have intestinal disorders. The intestine is the largest immune organ of the human body, and gut microbes can affect the immune function of the lungs through the gut-lung axis. Many lines of evidence supp...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Lei, Yang, Chung S., Liu, Yanan, Zhang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081431/
https://www.ncbi.nlm.nih.gov/pubmed/35548347
http://dx.doi.org/10.3389/fphar.2022.895193
_version_ 1784702986171187200
author Xu, Lei
Yang, Chung S.
Liu, Yanan
Zhang, Xin
author_facet Xu, Lei
Yang, Chung S.
Liu, Yanan
Zhang, Xin
author_sort Xu, Lei
collection PubMed
description Coronavirus disease 2019 (COVID-19) can disrupt the gut microbiota balance, and patients usually have intestinal disorders. The intestine is the largest immune organ of the human body, and gut microbes can affect the immune function of the lungs through the gut-lung axis. Many lines of evidence support the role of beneficial bacteria in enhancing human immunity, preventing pathogen colonization, and thereby reducing the incidence and severity of infection. In this article, we review the possible approach of modulating microbiota to help prevent and treat respiratory tract infections, including COVID-19, and discuss the possibility of using probiotics and prebiotics for this purpose. We also discuss the mechanism by which intestinal micro-flora regulate immunity and the effects of probiotics on the intestinal micro-ecological balance. Based on this understanding, we propose the use of probiotics and prebiotics to modulate gut microbiota for the prevention or alleviation of COVID-19 through the gut-lung axis.
format Online
Article
Text
id pubmed-9081431
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90814312022-05-10 Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis Xu, Lei Yang, Chung S. Liu, Yanan Zhang, Xin Front Pharmacol Pharmacology Coronavirus disease 2019 (COVID-19) can disrupt the gut microbiota balance, and patients usually have intestinal disorders. The intestine is the largest immune organ of the human body, and gut microbes can affect the immune function of the lungs through the gut-lung axis. Many lines of evidence support the role of beneficial bacteria in enhancing human immunity, preventing pathogen colonization, and thereby reducing the incidence and severity of infection. In this article, we review the possible approach of modulating microbiota to help prevent and treat respiratory tract infections, including COVID-19, and discuss the possibility of using probiotics and prebiotics for this purpose. We also discuss the mechanism by which intestinal micro-flora regulate immunity and the effects of probiotics on the intestinal micro-ecological balance. Based on this understanding, we propose the use of probiotics and prebiotics to modulate gut microbiota for the prevention or alleviation of COVID-19 through the gut-lung axis. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9081431/ /pubmed/35548347 http://dx.doi.org/10.3389/fphar.2022.895193 Text en Copyright © 2022 Xu, Yang, Liu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Xu, Lei
Yang, Chung S.
Liu, Yanan
Zhang, Xin
Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis
title Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis
title_full Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis
title_fullStr Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis
title_full_unstemmed Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis
title_short Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis
title_sort effective regulation of gut microbiota with probiotics and prebiotics may prevent or alleviate covid-19 through the gut-lung axis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081431/
https://www.ncbi.nlm.nih.gov/pubmed/35548347
http://dx.doi.org/10.3389/fphar.2022.895193
work_keys_str_mv AT xulei effectiveregulationofgutmicrobiotawithprobioticsandprebioticsmaypreventoralleviatecovid19throughthegutlungaxis
AT yangchungs effectiveregulationofgutmicrobiotawithprobioticsandprebioticsmaypreventoralleviatecovid19throughthegutlungaxis
AT liuyanan effectiveregulationofgutmicrobiotawithprobioticsandprebioticsmaypreventoralleviatecovid19throughthegutlungaxis
AT zhangxin effectiveregulationofgutmicrobiotawithprobioticsandprebioticsmaypreventoralleviatecovid19throughthegutlungaxis