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Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment

Polymeric nanocarriers were prepared via a dialysis method using three chitosan derivatives, N-benzyl-N,O-succinyl chitosan (BSCT), N-naphthyl-N,O-succinyl chitosan (NSCT), and N-octyl-N-O-succinyl chitosan (OSCT) and were coordinated to cisplatin. The nanocarrier properties and cytotoxicity on the...

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Autores principales: Trummer, Ronny, Rangsimawong, Worranan, Sajomsang, Warayuth, Kumpugdee-Vollrath, Mont, Opanasopit, Praneet, Tonglairoum, Prasopchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081559/
https://www.ncbi.nlm.nih.gov/pubmed/35540171
http://dx.doi.org/10.1039/c8ra03069c
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author Trummer, Ronny
Rangsimawong, Worranan
Sajomsang, Warayuth
Kumpugdee-Vollrath, Mont
Opanasopit, Praneet
Tonglairoum, Prasopchai
author_facet Trummer, Ronny
Rangsimawong, Worranan
Sajomsang, Warayuth
Kumpugdee-Vollrath, Mont
Opanasopit, Praneet
Tonglairoum, Prasopchai
author_sort Trummer, Ronny
collection PubMed
description Polymeric nanocarriers were prepared via a dialysis method using three chitosan derivatives, N-benzyl-N,O-succinyl chitosan (BSCT), N-naphthyl-N,O-succinyl chitosan (NSCT), and N-octyl-N-O-succinyl chitosan (OSCT) and were coordinated to cisplatin. The nanocarrier properties and cytotoxicity on the human carcinoma cells, HN22 (head and neck), were investigated. In addition, intracellular cisplatin accumulation, apoptosis induction and toxicity on renal cells were also evaluated. The findings revealed that the succinyl groups of the polymers were perfectly deprotonated and bound with cisplatin by co-ordinate bonds at pH 8.5. Among the derivatives, BSCT exhibited the highest cisplatin loading and release in simulated physiological medium. The cytotoxicities on HN22 cells of cisplatin-loaded BSCT nanocarriers were lower than that of free cisplatin, however, they presented a greater percentage of early apoptosis in HN22 cells and could decrease cisplatin induced renal cell death. In conclusion, the BSCT self-assembly nanocarrier might be a cisplatin carrier for sustained release, which provides prolonged antitumour treatment and reduced nephrotoxicity.
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spelling pubmed-90815592022-05-09 Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment Trummer, Ronny Rangsimawong, Worranan Sajomsang, Warayuth Kumpugdee-Vollrath, Mont Opanasopit, Praneet Tonglairoum, Prasopchai RSC Adv Chemistry Polymeric nanocarriers were prepared via a dialysis method using three chitosan derivatives, N-benzyl-N,O-succinyl chitosan (BSCT), N-naphthyl-N,O-succinyl chitosan (NSCT), and N-octyl-N-O-succinyl chitosan (OSCT) and were coordinated to cisplatin. The nanocarrier properties and cytotoxicity on the human carcinoma cells, HN22 (head and neck), were investigated. In addition, intracellular cisplatin accumulation, apoptosis induction and toxicity on renal cells were also evaluated. The findings revealed that the succinyl groups of the polymers were perfectly deprotonated and bound with cisplatin by co-ordinate bonds at pH 8.5. Among the derivatives, BSCT exhibited the highest cisplatin loading and release in simulated physiological medium. The cytotoxicities on HN22 cells of cisplatin-loaded BSCT nanocarriers were lower than that of free cisplatin, however, they presented a greater percentage of early apoptosis in HN22 cells and could decrease cisplatin induced renal cell death. In conclusion, the BSCT self-assembly nanocarrier might be a cisplatin carrier for sustained release, which provides prolonged antitumour treatment and reduced nephrotoxicity. The Royal Society of Chemistry 2018-06-22 /pmc/articles/PMC9081559/ /pubmed/35540171 http://dx.doi.org/10.1039/c8ra03069c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Trummer, Ronny
Rangsimawong, Worranan
Sajomsang, Warayuth
Kumpugdee-Vollrath, Mont
Opanasopit, Praneet
Tonglairoum, Prasopchai
Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment
title Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment
title_full Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment
title_fullStr Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment
title_full_unstemmed Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment
title_short Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment
title_sort chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081559/
https://www.ncbi.nlm.nih.gov/pubmed/35540171
http://dx.doi.org/10.1039/c8ra03069c
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