TAK1 inhibition by natural cyclopeptide RA-V promotes apoptosis and inhibits protective autophagy in Kras-dependent non-small-cell lung carcinoma cells

TAK1 kinase is required for the survival of Kras-dependent non-small-cell lung carcinoma (NSCLC) cells. Here, we report that the inhibition of TAK1 by a small natural cyclopeptide (RA-V) can promote apoptosis and inhibit protective autophagy in Kras-dependent NSCLC cells. Using short hairpin RNAs to...

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Detalles Bibliográficos
Autores principales: Yang, Jianhong, Yang, Tao, Yan, Wei, Li, Dan, Wang, Fang, Wang, Zhe, Guo, Yingjie, Bai, Peng, Tan, Ninghua, Chen, Lijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081588/
https://www.ncbi.nlm.nih.gov/pubmed/35540129
http://dx.doi.org/10.1039/c8ra04241a

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