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Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy

Alprazolam is a commonly prescribed benzodiazepine for anxiety or panic disorder, even in pregnant women. Information on the safety of alprazolam during pregnancy is insufficient. We aimed to evaluate pregnancy and neonatal outcomes after exposure to alprazolam during pregnancy. A prospective study...

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Autores principales: Lee, Hyunji, Koh, Jae-Whoan, Kim, Young-Ah, Chun, Kyoung-Chul, Han, Jung Yeol, Hwang, Jong Hee, Choi, June-Seek, Joo, Sung Hong, Kwon, Hye-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081603/
https://www.ncbi.nlm.nih.gov/pubmed/35548333
http://dx.doi.org/10.3389/fphar.2022.854562
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author Lee, Hyunji
Koh, Jae-Whoan
Kim, Young-Ah
Chun, Kyoung-Chul
Han, Jung Yeol
Hwang, Jong Hee
Choi, June-Seek
Joo, Sung Hong
Kwon, Hye-Young
author_facet Lee, Hyunji
Koh, Jae-Whoan
Kim, Young-Ah
Chun, Kyoung-Chul
Han, Jung Yeol
Hwang, Jong Hee
Choi, June-Seek
Joo, Sung Hong
Kwon, Hye-Young
author_sort Lee, Hyunji
collection PubMed
description Alprazolam is a commonly prescribed benzodiazepine for anxiety or panic disorder, even in pregnant women. Information on the safety of alprazolam during pregnancy is insufficient. We aimed to evaluate pregnancy and neonatal outcomes after exposure to alprazolam during pregnancy. A prospective study was conducted on 725 pregnancies from January 2000 to December 2019. Participants were recruited through the Korean Mother-Safe Program, a service providing information on drug-induced teratogenic risk during pregnancy and breastfeeding. Exposed (N = 96) and non-exposed (N = 629) women to alprazolam during pregnancy were selected and followed-up until delivery. Pregnancy outcomes, including spontaneous abortion, still birth, low birth weight (LBW), preterm birth, Apgar score (at 1 and 5 min), and malformations were measured and compared. Multivariable logistic regression was performed to examine the association between alprazolam exposure and outcomes. The mean age was 32.9 (SD 4.0) years in the alprazolam-exposed group and 31.8 (SD 3.8) years in the unexposed group (p = 0.008). The alprazolam exposure group demonstrated a significantly higher likelihood of pregnancy and neonatal outcomes: spontaneous abortion (OR = 2.38; 95% CI 1.20–4.69), LBW (OR = 3.65; 95% CI 1.22–11.00), and Apgar score at 1 min ≤ 7 (OR = 2.19; 95% CI 1.02–4.67). There was no significant difference in congenital abnormalities between the exposure and non-exposure groups. Our findings confirmed that alprazolam exposure during pregnancy was significantly associated with adverse pregnancy and neonatal outcomes, including spontaneous abortion, low birth weight, and Apgar score at 1 min ≤ 7. Alprazolam during pregnancy should be appropriately regulated and monitored.
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spelling pubmed-90816032022-05-10 Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy Lee, Hyunji Koh, Jae-Whoan Kim, Young-Ah Chun, Kyoung-Chul Han, Jung Yeol Hwang, Jong Hee Choi, June-Seek Joo, Sung Hong Kwon, Hye-Young Front Pharmacol Pharmacology Alprazolam is a commonly prescribed benzodiazepine for anxiety or panic disorder, even in pregnant women. Information on the safety of alprazolam during pregnancy is insufficient. We aimed to evaluate pregnancy and neonatal outcomes after exposure to alprazolam during pregnancy. A prospective study was conducted on 725 pregnancies from January 2000 to December 2019. Participants were recruited through the Korean Mother-Safe Program, a service providing information on drug-induced teratogenic risk during pregnancy and breastfeeding. Exposed (N = 96) and non-exposed (N = 629) women to alprazolam during pregnancy were selected and followed-up until delivery. Pregnancy outcomes, including spontaneous abortion, still birth, low birth weight (LBW), preterm birth, Apgar score (at 1 and 5 min), and malformations were measured and compared. Multivariable logistic regression was performed to examine the association between alprazolam exposure and outcomes. The mean age was 32.9 (SD 4.0) years in the alprazolam-exposed group and 31.8 (SD 3.8) years in the unexposed group (p = 0.008). The alprazolam exposure group demonstrated a significantly higher likelihood of pregnancy and neonatal outcomes: spontaneous abortion (OR = 2.38; 95% CI 1.20–4.69), LBW (OR = 3.65; 95% CI 1.22–11.00), and Apgar score at 1 min ≤ 7 (OR = 2.19; 95% CI 1.02–4.67). There was no significant difference in congenital abnormalities between the exposure and non-exposure groups. Our findings confirmed that alprazolam exposure during pregnancy was significantly associated with adverse pregnancy and neonatal outcomes, including spontaneous abortion, low birth weight, and Apgar score at 1 min ≤ 7. Alprazolam during pregnancy should be appropriately regulated and monitored. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9081603/ /pubmed/35548333 http://dx.doi.org/10.3389/fphar.2022.854562 Text en Copyright © 2022 Lee, Koh, Kim, Chun, Han, Hwang, Choi, Joo and Kwon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lee, Hyunji
Koh, Jae-Whoan
Kim, Young-Ah
Chun, Kyoung-Chul
Han, Jung Yeol
Hwang, Jong Hee
Choi, June-Seek
Joo, Sung Hong
Kwon, Hye-Young
Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy
title Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy
title_full Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy
title_fullStr Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy
title_full_unstemmed Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy
title_short Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy
title_sort pregnancy and neonatal outcomes after exposure to alprazolam in pregnancy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081603/
https://www.ncbi.nlm.nih.gov/pubmed/35548333
http://dx.doi.org/10.3389/fphar.2022.854562
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