Cargando…

Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation

The synovial tissue is an immunologically challenging environment where, under homeostatic conditions, highly specialized subsets of immune-regulatory macrophages and fibroblasts constantly prevent synovial inflammation in response to cartilage- and synovial fluid-derived danger signals that accumul...

Descripción completa

Detalles Bibliográficos
Autores principales: Knab, Katharina, Chambers, David, Krönke, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081642/
https://www.ncbi.nlm.nih.gov/pubmed/35547214
http://dx.doi.org/10.3389/fmed.2022.862161
_version_ 1784703032437506048
author Knab, Katharina
Chambers, David
Krönke, Gerhard
author_facet Knab, Katharina
Chambers, David
Krönke, Gerhard
author_sort Knab, Katharina
collection PubMed
description The synovial tissue is an immunologically challenging environment where, under homeostatic conditions, highly specialized subsets of immune-regulatory macrophages and fibroblasts constantly prevent synovial inflammation in response to cartilage- and synovial fluid-derived danger signals that accumulate in response to mechanical stress. During inflammatory joint diseases, this immune-regulatory environment becomes perturbed and activated synovial fibroblasts and infiltrating immune cells start to contribute to synovial inflammation and joint destruction. This review summarizes our current understanding of the phenotypic and molecular characteristics of resident synovial macrophages and fibroblasts and highlights their crosstalk during joint homeostasis and joint inflammation, which is increasingly appreciated as vital to understand the molecular basis of prevalent inflammatory joint diseases such as rheumatoid arthritis.
format Online
Article
Text
id pubmed-9081642
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90816422022-05-10 Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation Knab, Katharina Chambers, David Krönke, Gerhard Front Med (Lausanne) Medicine The synovial tissue is an immunologically challenging environment where, under homeostatic conditions, highly specialized subsets of immune-regulatory macrophages and fibroblasts constantly prevent synovial inflammation in response to cartilage- and synovial fluid-derived danger signals that accumulate in response to mechanical stress. During inflammatory joint diseases, this immune-regulatory environment becomes perturbed and activated synovial fibroblasts and infiltrating immune cells start to contribute to synovial inflammation and joint destruction. This review summarizes our current understanding of the phenotypic and molecular characteristics of resident synovial macrophages and fibroblasts and highlights their crosstalk during joint homeostasis and joint inflammation, which is increasingly appreciated as vital to understand the molecular basis of prevalent inflammatory joint diseases such as rheumatoid arthritis. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9081642/ /pubmed/35547214 http://dx.doi.org/10.3389/fmed.2022.862161 Text en Copyright © 2022 Knab, Chambers and Krönke. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Knab, Katharina
Chambers, David
Krönke, Gerhard
Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation
title Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation
title_full Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation
title_fullStr Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation
title_full_unstemmed Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation
title_short Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation
title_sort synovial macrophage and fibroblast heterogeneity in joint homeostasis and inflammation
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081642/
https://www.ncbi.nlm.nih.gov/pubmed/35547214
http://dx.doi.org/10.3389/fmed.2022.862161
work_keys_str_mv AT knabkatharina synovialmacrophageandfibroblastheterogeneityinjointhomeostasisandinflammation
AT chambersdavid synovialmacrophageandfibroblastheterogeneityinjointhomeostasisandinflammation
AT kronkegerhard synovialmacrophageandfibroblastheterogeneityinjointhomeostasisandinflammation