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Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation
The synovial tissue is an immunologically challenging environment where, under homeostatic conditions, highly specialized subsets of immune-regulatory macrophages and fibroblasts constantly prevent synovial inflammation in response to cartilage- and synovial fluid-derived danger signals that accumul...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081642/ https://www.ncbi.nlm.nih.gov/pubmed/35547214 http://dx.doi.org/10.3389/fmed.2022.862161 |
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author | Knab, Katharina Chambers, David Krönke, Gerhard |
author_facet | Knab, Katharina Chambers, David Krönke, Gerhard |
author_sort | Knab, Katharina |
collection | PubMed |
description | The synovial tissue is an immunologically challenging environment where, under homeostatic conditions, highly specialized subsets of immune-regulatory macrophages and fibroblasts constantly prevent synovial inflammation in response to cartilage- and synovial fluid-derived danger signals that accumulate in response to mechanical stress. During inflammatory joint diseases, this immune-regulatory environment becomes perturbed and activated synovial fibroblasts and infiltrating immune cells start to contribute to synovial inflammation and joint destruction. This review summarizes our current understanding of the phenotypic and molecular characteristics of resident synovial macrophages and fibroblasts and highlights their crosstalk during joint homeostasis and joint inflammation, which is increasingly appreciated as vital to understand the molecular basis of prevalent inflammatory joint diseases such as rheumatoid arthritis. |
format | Online Article Text |
id | pubmed-9081642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90816422022-05-10 Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation Knab, Katharina Chambers, David Krönke, Gerhard Front Med (Lausanne) Medicine The synovial tissue is an immunologically challenging environment where, under homeostatic conditions, highly specialized subsets of immune-regulatory macrophages and fibroblasts constantly prevent synovial inflammation in response to cartilage- and synovial fluid-derived danger signals that accumulate in response to mechanical stress. During inflammatory joint diseases, this immune-regulatory environment becomes perturbed and activated synovial fibroblasts and infiltrating immune cells start to contribute to synovial inflammation and joint destruction. This review summarizes our current understanding of the phenotypic and molecular characteristics of resident synovial macrophages and fibroblasts and highlights their crosstalk during joint homeostasis and joint inflammation, which is increasingly appreciated as vital to understand the molecular basis of prevalent inflammatory joint diseases such as rheumatoid arthritis. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9081642/ /pubmed/35547214 http://dx.doi.org/10.3389/fmed.2022.862161 Text en Copyright © 2022 Knab, Chambers and Krönke. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Knab, Katharina Chambers, David Krönke, Gerhard Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation |
title | Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation |
title_full | Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation |
title_fullStr | Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation |
title_full_unstemmed | Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation |
title_short | Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation |
title_sort | synovial macrophage and fibroblast heterogeneity in joint homeostasis and inflammation |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081642/ https://www.ncbi.nlm.nih.gov/pubmed/35547214 http://dx.doi.org/10.3389/fmed.2022.862161 |
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