Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens

A chemical study of the common species Albatrellus confluens present in Yunnan province, southwest China led to the identification of a pair of epimers named albatredines A (1) and B (2). They feature a natural unprecedented 1,2,4-oxadiazolidin-5-one skeleton. The acyl substitution pattern and compl...

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Autores principales: Zhang, Shuaibing, Huang, Ying, He, Shijun, Chen, Heping, Li, Zhenghui, Wu, Bin, Zuo, Jianping, Feng, Tao, Liu, Jikai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081739/
https://www.ncbi.nlm.nih.gov/pubmed/35540281
http://dx.doi.org/10.1039/c8ra04226h
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author Zhang, Shuaibing
Huang, Ying
He, Shijun
Chen, Heping
Li, Zhenghui
Wu, Bin
Zuo, Jianping
Feng, Tao
Liu, Jikai
author_facet Zhang, Shuaibing
Huang, Ying
He, Shijun
Chen, Heping
Li, Zhenghui
Wu, Bin
Zuo, Jianping
Feng, Tao
Liu, Jikai
author_sort Zhang, Shuaibing
collection PubMed
description A chemical study of the common species Albatrellus confluens present in Yunnan province, southwest China led to the identification of a pair of epimers named albatredines A (1) and B (2). They feature a natural unprecedented 1,2,4-oxadiazolidin-5-one skeleton. The acyl substitution pattern and complete configurational assignments were deduced from the comparison between experimental and theoretical (13)C NMR and ECD data, respectively. Bioassay results showed that compound 1 exhibited a weak immunosuppressive activity against the concanavalin A-induced T lymphocyte cell proliferation (IC(50) 2.99 μM).
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spelling pubmed-90817392022-05-09 Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens Zhang, Shuaibing Huang, Ying He, Shijun Chen, Heping Li, Zhenghui Wu, Bin Zuo, Jianping Feng, Tao Liu, Jikai RSC Adv Chemistry A chemical study of the common species Albatrellus confluens present in Yunnan province, southwest China led to the identification of a pair of epimers named albatredines A (1) and B (2). They feature a natural unprecedented 1,2,4-oxadiazolidin-5-one skeleton. The acyl substitution pattern and complete configurational assignments were deduced from the comparison between experimental and theoretical (13)C NMR and ECD data, respectively. Bioassay results showed that compound 1 exhibited a weak immunosuppressive activity against the concanavalin A-induced T lymphocyte cell proliferation (IC(50) 2.99 μM). The Royal Society of Chemistry 2018-07-02 /pmc/articles/PMC9081739/ /pubmed/35540281 http://dx.doi.org/10.1039/c8ra04226h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Zhang, Shuaibing
Huang, Ying
He, Shijun
Chen, Heping
Li, Zhenghui
Wu, Bin
Zuo, Jianping
Feng, Tao
Liu, Jikai
Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens
title Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens
title_full Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens
title_fullStr Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens
title_full_unstemmed Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens
title_short Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens
title_sort albatredines a and b, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom albatrellus confluens
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081739/
https://www.ncbi.nlm.nih.gov/pubmed/35540281
http://dx.doi.org/10.1039/c8ra04226h
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