On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth

In a previous paper (RSC Adv., 2015, 5, 66886–66893), we showed that the combination of silver nanoparticles (NanoAg) with doxycycline (DO) culminated in an increased bactericidal activity towards E. coli. Herein we further investigated the metabolic changes that occurred on Staphylococcus aureus up...

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Autores principales: Silva, Heloiza F. O., de Lima, Rayane P., da Costa, Fernanda S. L., Moraes, Edgar P., Melo, Maria C. N., Sant’Anna, Celso, Eugênio, Mateus, Gasparotto, Luiz H. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081745/
https://www.ncbi.nlm.nih.gov/pubmed/35540305
http://dx.doi.org/10.1039/c8ra02176g
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author Silva, Heloiza F. O.
de Lima, Rayane P.
da Costa, Fernanda S. L.
Moraes, Edgar P.
Melo, Maria C. N.
Sant’Anna, Celso
Eugênio, Mateus
Gasparotto, Luiz H. S.
author_facet Silva, Heloiza F. O.
de Lima, Rayane P.
da Costa, Fernanda S. L.
Moraes, Edgar P.
Melo, Maria C. N.
Sant’Anna, Celso
Eugênio, Mateus
Gasparotto, Luiz H. S.
author_sort Silva, Heloiza F. O.
collection PubMed
description In a previous paper (RSC Adv., 2015, 5, 66886–66893), we showed that the combination of silver nanoparticles (NanoAg) with doxycycline (DO) culminated in an increased bactericidal activity towards E. coli. Herein we further investigated the metabolic changes that occurred on Staphylococcus aureus upon exposure to NanoAg with the help of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) coupled with multivariate data analysis. It has been discovered that the combination of DO with NanoAg produced metabolic changes in S. aureus that were not simply the overlap of the treatments with DO and NanoAg separately. Our results suggest that DO and NanoAg act synergistically to impede protein synthesis by the bacteria.
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spelling pubmed-90817452022-05-09 On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth Silva, Heloiza F. O. de Lima, Rayane P. da Costa, Fernanda S. L. Moraes, Edgar P. Melo, Maria C. N. Sant’Anna, Celso Eugênio, Mateus Gasparotto, Luiz H. S. RSC Adv Chemistry In a previous paper (RSC Adv., 2015, 5, 66886–66893), we showed that the combination of silver nanoparticles (NanoAg) with doxycycline (DO) culminated in an increased bactericidal activity towards E. coli. Herein we further investigated the metabolic changes that occurred on Staphylococcus aureus upon exposure to NanoAg with the help of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) coupled with multivariate data analysis. It has been discovered that the combination of DO with NanoAg produced metabolic changes in S. aureus that were not simply the overlap of the treatments with DO and NanoAg separately. Our results suggest that DO and NanoAg act synergistically to impede protein synthesis by the bacteria. The Royal Society of Chemistry 2018-06-28 /pmc/articles/PMC9081745/ /pubmed/35540305 http://dx.doi.org/10.1039/c8ra02176g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Silva, Heloiza F. O.
de Lima, Rayane P.
da Costa, Fernanda S. L.
Moraes, Edgar P.
Melo, Maria C. N.
Sant’Anna, Celso
Eugênio, Mateus
Gasparotto, Luiz H. S.
On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth
title On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth
title_full On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth
title_fullStr On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth
title_full_unstemmed On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth
title_short On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth
title_sort on the synergy between silver nanoparticles and doxycycline towards the inhibition of staphylococcus aureus growth
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081745/
https://www.ncbi.nlm.nih.gov/pubmed/35540305
http://dx.doi.org/10.1039/c8ra02176g
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