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A Comparison of Single- and Multi-Echo Processing of Functional MRI Data During Overt Autobiographical Recall
Recent years have seen an increase in the use of multi-echo fMRI designs by cognitive neuroscientists. Acquiring multiple echoes allows one to increase contrast-to-noise; reduce signal dropout and thermal noise; and identify nuisance signal components in BOLD data. At the same time, multi-echo acqui...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081814/ https://www.ncbi.nlm.nih.gov/pubmed/35546886 http://dx.doi.org/10.3389/fnins.2022.854387 |
Sumario: | Recent years have seen an increase in the use of multi-echo fMRI designs by cognitive neuroscientists. Acquiring multiple echoes allows one to increase contrast-to-noise; reduce signal dropout and thermal noise; and identify nuisance signal components in BOLD data. At the same time, multi-echo acquisitions increase data processing complexity and may incur a cost to the temporal and spatial resolution of the acquired data. Here, we re-examine a multi-echo dataset previously analyzed using multi-echo independent components analysis (ME-ICA) and focused on hippocampal activity during the overtly spoken recall of recent and remote autobiographical memories. The goal of the present series of analyses was to determine if ME-ICA’s theoretical denoising benefits might lead to a practical difference in the overall conclusions reached. Compared to single-echo (SE) data, ME-ICA led to qualitatively different findings regarding hippocampal contributions to autobiographical recall: whereas the SE analysis largely failed to reveal hippocampal activity relative to an active baseline, ME-ICA results supported predictions of the Standard Model of Consolidation and a time limited hippocampal involvement. These data provide a practical example of the benefits multi-echo denoising in a naturalistic memory paradigm and demonstrate how they can be used to address long-standing theoretical questions. |
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