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Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats

Evidence in the literature suggests that sleep deprivation during early-life developmental stages, by impacting important processes such as the reward circuit maturation, may increase the vulnerability for alcohol and substance use. The mechanisms involved are not fully understood. In this study, ut...

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Autores principales: Atrooz, Fatin, Alrousan, Ghalya, Hassan, Arham, Salim, Samina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081815/
https://www.ncbi.nlm.nih.gov/pubmed/35546871
http://dx.doi.org/10.3389/fnins.2022.856120
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author Atrooz, Fatin
Alrousan, Ghalya
Hassan, Arham
Salim, Samina
author_facet Atrooz, Fatin
Alrousan, Ghalya
Hassan, Arham
Salim, Samina
author_sort Atrooz, Fatin
collection PubMed
description Evidence in the literature suggests that sleep deprivation during early-life developmental stages, by impacting important processes such as the reward circuit maturation, may increase the vulnerability for alcohol and substance use. The mechanisms involved are not fully understood. In this study, utilizing our previously established model, we examined the impact of early-life sleep deprivation on alcohol consumption in adolescent rats. Male Sprague Dawley rats served as either the control (CON) or sleep-deprived (SD) group. Sleep deprivation was induced using a Pinnacle automated sleep deprivation apparatus. The SD group of rats was sleep deprived for 6–8 h/day for 14 days from postnatal day (PND)19 to PND32. At PND33, anxiety- and depression-like behaviors were assessed in rats using elevated plus maze and sucrose splash test, respectively. At PND39, alcohol consumption was assessed in rats for five consecutive days using the two-bottle choice paradigm, water versus 5% ethanol. SD rats exhibited significant anxiety- and depression-like behaviors as compared to CON rats. Interestingly, SD rats consumed a larger volume of alcohol when compared to CON rats, which was significantly higher at day 5 (mean of alcohol consumption (ml) ± SD; CON = 6.67 ± 3.42; SD = 19.00 ± 6.05, p = 0.0126). SD rats also showed high preference for alcohol over water, which was significantly higher at day 5 (mean of alcohol preference (%) ± SD; CON = 26.85 ± 14.97; SD = 57.69 ± 5.61, p = 0.014). Our data suggest that early-life sleep deprivation enhanced alcohol consumption in adolescent rats.
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spelling pubmed-90818152022-05-10 Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats Atrooz, Fatin Alrousan, Ghalya Hassan, Arham Salim, Samina Front Neurosci Neuroscience Evidence in the literature suggests that sleep deprivation during early-life developmental stages, by impacting important processes such as the reward circuit maturation, may increase the vulnerability for alcohol and substance use. The mechanisms involved are not fully understood. In this study, utilizing our previously established model, we examined the impact of early-life sleep deprivation on alcohol consumption in adolescent rats. Male Sprague Dawley rats served as either the control (CON) or sleep-deprived (SD) group. Sleep deprivation was induced using a Pinnacle automated sleep deprivation apparatus. The SD group of rats was sleep deprived for 6–8 h/day for 14 days from postnatal day (PND)19 to PND32. At PND33, anxiety- and depression-like behaviors were assessed in rats using elevated plus maze and sucrose splash test, respectively. At PND39, alcohol consumption was assessed in rats for five consecutive days using the two-bottle choice paradigm, water versus 5% ethanol. SD rats exhibited significant anxiety- and depression-like behaviors as compared to CON rats. Interestingly, SD rats consumed a larger volume of alcohol when compared to CON rats, which was significantly higher at day 5 (mean of alcohol consumption (ml) ± SD; CON = 6.67 ± 3.42; SD = 19.00 ± 6.05, p = 0.0126). SD rats also showed high preference for alcohol over water, which was significantly higher at day 5 (mean of alcohol preference (%) ± SD; CON = 26.85 ± 14.97; SD = 57.69 ± 5.61, p = 0.014). Our data suggest that early-life sleep deprivation enhanced alcohol consumption in adolescent rats. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9081815/ /pubmed/35546871 http://dx.doi.org/10.3389/fnins.2022.856120 Text en Copyright © 2022 Atrooz, Alrousan, Hassan and Salim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Atrooz, Fatin
Alrousan, Ghalya
Hassan, Arham
Salim, Samina
Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats
title Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats
title_full Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats
title_fullStr Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats
title_full_unstemmed Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats
title_short Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats
title_sort early-life sleep deprivation enhanced alcohol consumption in adolescent rats
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081815/
https://www.ncbi.nlm.nih.gov/pubmed/35546871
http://dx.doi.org/10.3389/fnins.2022.856120
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