A novel near-infrared fluorescent probe for highly selective recognition of hydrogen sulfide and imaging in living cells

A novel near-infrared fluorescent probe (L) based on a 1,4-diethyl-1,2,3,4-tetrahydro-7H-pyrano[2,3-g]quinoxalin-7-one scaffold has been synthesized and characterized. Probe L displays highly selective and sensitive recognition to H(2)S over various anions and biological thiols with a large Stokes s...

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Detalles Bibliográficos
Autores principales: Zhong, Keli, Deng, Longlong, Zhao, Jie, Yan, Xiaomei, Sun, Tong, Li, Jianrong, Tang, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081853/
https://www.ncbi.nlm.nih.gov/pubmed/35540263
http://dx.doi.org/10.1039/c8ra03457e
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author Zhong, Keli
Deng, Longlong
Zhao, Jie
Yan, Xiaomei
Sun, Tong
Li, Jianrong
Tang, Lijun
author_facet Zhong, Keli
Deng, Longlong
Zhao, Jie
Yan, Xiaomei
Sun, Tong
Li, Jianrong
Tang, Lijun
author_sort Zhong, Keli
collection PubMed
description A novel near-infrared fluorescent probe (L) based on a 1,4-diethyl-1,2,3,4-tetrahydro-7H-pyrano[2,3-g]quinoxalin-7-one scaffold has been synthesized and characterized. Probe L displays highly selective and sensitive recognition to H(2)S over various anions and biological thiols with a large Stokes shift (125 nm) in THF/H(2)O (6/4, v/v, Tris–HCl 10 mM, pH = 7.4). This probe exhibits turn-on fluorescence for H(2)S through HS(−) induced thiolysis of dinitrophenyl ether. Confocal laser scanning micrographs of MCF-7 cells incubated with L confirm that L is cell-permeable and can successfully detect H(2)S in living cells.
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spelling pubmed-90818532022-05-09 A novel near-infrared fluorescent probe for highly selective recognition of hydrogen sulfide and imaging in living cells Zhong, Keli Deng, Longlong Zhao, Jie Yan, Xiaomei Sun, Tong Li, Jianrong Tang, Lijun RSC Adv Chemistry A novel near-infrared fluorescent probe (L) based on a 1,4-diethyl-1,2,3,4-tetrahydro-7H-pyrano[2,3-g]quinoxalin-7-one scaffold has been synthesized and characterized. Probe L displays highly selective and sensitive recognition to H(2)S over various anions and biological thiols with a large Stokes shift (125 nm) in THF/H(2)O (6/4, v/v, Tris–HCl 10 mM, pH = 7.4). This probe exhibits turn-on fluorescence for H(2)S through HS(−) induced thiolysis of dinitrophenyl ether. Confocal laser scanning micrographs of MCF-7 cells incubated with L confirm that L is cell-permeable and can successfully detect H(2)S in living cells. The Royal Society of Chemistry 2018-07-02 /pmc/articles/PMC9081853/ /pubmed/35540263 http://dx.doi.org/10.1039/c8ra03457e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Zhong, Keli
Deng, Longlong
Zhao, Jie
Yan, Xiaomei
Sun, Tong
Li, Jianrong
Tang, Lijun
A novel near-infrared fluorescent probe for highly selective recognition of hydrogen sulfide and imaging in living cells
title A novel near-infrared fluorescent probe for highly selective recognition of hydrogen sulfide and imaging in living cells
title_full A novel near-infrared fluorescent probe for highly selective recognition of hydrogen sulfide and imaging in living cells
title_fullStr A novel near-infrared fluorescent probe for highly selective recognition of hydrogen sulfide and imaging in living cells
title_full_unstemmed A novel near-infrared fluorescent probe for highly selective recognition of hydrogen sulfide and imaging in living cells
title_short A novel near-infrared fluorescent probe for highly selective recognition of hydrogen sulfide and imaging in living cells
title_sort novel near-infrared fluorescent probe for highly selective recognition of hydrogen sulfide and imaging in living cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081853/
https://www.ncbi.nlm.nih.gov/pubmed/35540263
http://dx.doi.org/10.1039/c8ra03457e
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