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Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats

Heart failure is a complex end stage result of various cardiovascular diseases, and has a poor prognosis. The mechanisms for the development and progression of heart failure have always been an important topic in cardiovascular research, and previous studies have shown that thymoquinone (TQ) protect...

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Autores principales: Pei, Zuowei, Hu, Jiahui, Bai, Qianru, Liu, Baiting, Cheng, Dong, Liu, Hainiang, Na, Rongmei, Yu, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081863/
https://www.ncbi.nlm.nih.gov/pubmed/35540763
http://dx.doi.org/10.1039/c8ra00975a
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author Pei, Zuowei
Hu, Jiahui
Bai, Qianru
Liu, Baiting
Cheng, Dong
Liu, Hainiang
Na, Rongmei
Yu, Qin
author_facet Pei, Zuowei
Hu, Jiahui
Bai, Qianru
Liu, Baiting
Cheng, Dong
Liu, Hainiang
Na, Rongmei
Yu, Qin
author_sort Pei, Zuowei
collection PubMed
description Heart failure is a complex end stage result of various cardiovascular diseases, and has a poor prognosis. The mechanisms for the development and progression of heart failure have always been an important topic in cardiovascular research, and previous studies have shown that thymoquinone (TQ) protects against cardiotoxicity and cardiac damage. The aim of this study was to investigate the possible protective effects of thymoquinone against cardiac damage in doxorubicin (DOX)-induced heart failure in Sprague-Dawley Rats (SDR). Forty-five male SDR were randomly divided into three groups and administered different treatment regimens for 8 weeks. Left ventricular fractional shortening (LVFS) and ejection fraction (LVEF) were higher in the DOX + TQ group than those in the DOX group. Significant pathophysiology changes (HE and Masson staining) were observed in rats of the DOX group compared to those of the DOX + TQ group. The addition of Thymoquinone inhibited DOX-induced cardiac fibrosis (TGF-β, Smad3, collagen I, collagen III, and α-SMA) and apoptosis (P53, bcl-2, caspase-3, caspase-9, and BAX) in SDR, indicating that thymoquinone may be a potential therapeutic target for cardiac damage caused by DOX-induced heart failure.
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spelling pubmed-90818632022-05-09 Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats Pei, Zuowei Hu, Jiahui Bai, Qianru Liu, Baiting Cheng, Dong Liu, Hainiang Na, Rongmei Yu, Qin RSC Adv Chemistry Heart failure is a complex end stage result of various cardiovascular diseases, and has a poor prognosis. The mechanisms for the development and progression of heart failure have always been an important topic in cardiovascular research, and previous studies have shown that thymoquinone (TQ) protects against cardiotoxicity and cardiac damage. The aim of this study was to investigate the possible protective effects of thymoquinone against cardiac damage in doxorubicin (DOX)-induced heart failure in Sprague-Dawley Rats (SDR). Forty-five male SDR were randomly divided into three groups and administered different treatment regimens for 8 weeks. Left ventricular fractional shortening (LVFS) and ejection fraction (LVEF) were higher in the DOX + TQ group than those in the DOX group. Significant pathophysiology changes (HE and Masson staining) were observed in rats of the DOX group compared to those of the DOX + TQ group. The addition of Thymoquinone inhibited DOX-induced cardiac fibrosis (TGF-β, Smad3, collagen I, collagen III, and α-SMA) and apoptosis (P53, bcl-2, caspase-3, caspase-9, and BAX) in SDR, indicating that thymoquinone may be a potential therapeutic target for cardiac damage caused by DOX-induced heart failure. The Royal Society of Chemistry 2018-04-18 /pmc/articles/PMC9081863/ /pubmed/35540763 http://dx.doi.org/10.1039/c8ra00975a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Pei, Zuowei
Hu, Jiahui
Bai, Qianru
Liu, Baiting
Cheng, Dong
Liu, Hainiang
Na, Rongmei
Yu, Qin
Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats
title Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats
title_full Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats
title_fullStr Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats
title_full_unstemmed Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats
title_short Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats
title_sort thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in sprague-dawley rats
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081863/
https://www.ncbi.nlm.nih.gov/pubmed/35540763
http://dx.doi.org/10.1039/c8ra00975a
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