Synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process

A radical trifluoromethylation reaction of tertiary enamides was investigated and trifluoromethyl-containing isoindolinones were prepared under mild conditions. Using TMSCF(3) as a radical source, PhI(OAc)(2) as an oxidant and KHF(2) as an additive, tertiary enamides were converted to isoindolinones...

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Detalles Bibliográficos
Autores principales: Yu, Hui, Jiao, Mingdong, Fang, Xiaowei, Xuan, Pengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081866/
https://www.ncbi.nlm.nih.gov/pubmed/35540298
http://dx.doi.org/10.1039/c8ra03696a
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author Yu, Hui
Jiao, Mingdong
Fang, Xiaowei
Xuan, Pengfei
author_facet Yu, Hui
Jiao, Mingdong
Fang, Xiaowei
Xuan, Pengfei
author_sort Yu, Hui
collection PubMed
description A radical trifluoromethylation reaction of tertiary enamides was investigated and trifluoromethyl-containing isoindolinones were prepared under mild conditions. Using TMSCF(3) as a radical source, PhI(OAc)(2) as an oxidant and KHF(2) as an additive, tertiary enamides were converted to isoindolinones via a cascade addition and cyclization process in moderate to good yields.
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spelling pubmed-90818662022-05-09 Synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process Yu, Hui Jiao, Mingdong Fang, Xiaowei Xuan, Pengfei RSC Adv Chemistry A radical trifluoromethylation reaction of tertiary enamides was investigated and trifluoromethyl-containing isoindolinones were prepared under mild conditions. Using TMSCF(3) as a radical source, PhI(OAc)(2) as an oxidant and KHF(2) as an additive, tertiary enamides were converted to isoindolinones via a cascade addition and cyclization process in moderate to good yields. The Royal Society of Chemistry 2018-07-03 /pmc/articles/PMC9081866/ /pubmed/35540298 http://dx.doi.org/10.1039/c8ra03696a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yu, Hui
Jiao, Mingdong
Fang, Xiaowei
Xuan, Pengfei
Synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process
title Synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process
title_full Synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process
title_fullStr Synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process
title_full_unstemmed Synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process
title_short Synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process
title_sort synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081866/
https://www.ncbi.nlm.nih.gov/pubmed/35540298
http://dx.doi.org/10.1039/c8ra03696a
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AT fangxiaowei synthesisoftrifluoromethylcontainingisoindolinonesfromtertiaryenamidesviaacascaderadicaladditionandcyclizationprocess
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