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Synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process
A radical trifluoromethylation reaction of tertiary enamides was investigated and trifluoromethyl-containing isoindolinones were prepared under mild conditions. Using TMSCF(3) as a radical source, PhI(OAc)(2) as an oxidant and KHF(2) as an additive, tertiary enamides were converted to isoindolinones...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081866/ https://www.ncbi.nlm.nih.gov/pubmed/35540298 http://dx.doi.org/10.1039/c8ra03696a |