Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons

Direct reprogramming based on genetic factors resembles a promising strategy to replace lost cells in degenerative diseases such as Parkinson's disease. For this, we developed a knock‐in mouse line carrying a dual dCas9 transactivator system (dCAM) allowing the conditional in vivo activation of...

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Detalles Bibliográficos
Autores principales: Giehrl‐Schwab, Jessica, Giesert, Florian, Rauser, Benedict, Lao, Chu Lan, Hembach, Sina, Lefort, Sandrine, Ibarra, Ignacio L, Koupourtidou, Christina, Luecken, Malte Daniel, Truong, Dong‐Jiunn Jeffery, Fischer‐Sternjak, Judith, Masserdotti, Giacomo, Prakash, Nilima, Ninkovic, Jovica, Hölter, Sabine M, Vogt Weisenhorn, Daniela M, Theis, Fabian J, Götz, Magdalena, Wurst, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081909/
https://www.ncbi.nlm.nih.gov/pubmed/35373464
http://dx.doi.org/10.15252/emmm.202114797

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