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Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery
Despite careful preoperative planning, surgical flaps are prone to ischemic tissue damage and ischemia–reperfusion injury. The resulting wound breakdown and flap necrosis increase both treatment costs and patient morbidity. Hence, there is a need for strategies to promote flap survival and prevent i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081973/ https://www.ncbi.nlm.nih.gov/pubmed/35548348 http://dx.doi.org/10.3389/fphar.2022.864351 |
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author | Weinzierl, Andrea Ampofo, Emmanuel Menger, Michael D. Laschke, Matthias W. |
author_facet | Weinzierl, Andrea Ampofo, Emmanuel Menger, Michael D. Laschke, Matthias W. |
author_sort | Weinzierl, Andrea |
collection | PubMed |
description | Despite careful preoperative planning, surgical flaps are prone to ischemic tissue damage and ischemia–reperfusion injury. The resulting wound breakdown and flap necrosis increase both treatment costs and patient morbidity. Hence, there is a need for strategies to promote flap survival and prevent ischemia-induced tissue damage. Phytochemicals, defined as non-essential, bioactive, and plant-derived molecules, are attractive candidates for perioperative treatment as they have little to no side effects and are well tolerated by most patients. Furthermore, they have been shown to exert beneficial combinations of pro-angiogenic, anti-inflammatory, anti-oxidant, and anti-apoptotic effects. This review provides an overview of bioactive phytochemicals that have been used to increase flap survival in preclinical animal models and discusses the underlying molecular and cellular mechanisms. |
format | Online Article Text |
id | pubmed-9081973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90819732022-05-10 Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery Weinzierl, Andrea Ampofo, Emmanuel Menger, Michael D. Laschke, Matthias W. Front Pharmacol Pharmacology Despite careful preoperative planning, surgical flaps are prone to ischemic tissue damage and ischemia–reperfusion injury. The resulting wound breakdown and flap necrosis increase both treatment costs and patient morbidity. Hence, there is a need for strategies to promote flap survival and prevent ischemia-induced tissue damage. Phytochemicals, defined as non-essential, bioactive, and plant-derived molecules, are attractive candidates for perioperative treatment as they have little to no side effects and are well tolerated by most patients. Furthermore, they have been shown to exert beneficial combinations of pro-angiogenic, anti-inflammatory, anti-oxidant, and anti-apoptotic effects. This review provides an overview of bioactive phytochemicals that have been used to increase flap survival in preclinical animal models and discusses the underlying molecular and cellular mechanisms. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9081973/ /pubmed/35548348 http://dx.doi.org/10.3389/fphar.2022.864351 Text en Copyright © 2022 Weinzierl, Ampofo, Menger and Laschke. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Weinzierl, Andrea Ampofo, Emmanuel Menger, Michael D. Laschke, Matthias W. Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery |
title | Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery |
title_full | Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery |
title_fullStr | Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery |
title_full_unstemmed | Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery |
title_short | Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery |
title_sort | tissue-protective mechanisms of bioactive phytochemicals in flap surgery |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081973/ https://www.ncbi.nlm.nih.gov/pubmed/35548348 http://dx.doi.org/10.3389/fphar.2022.864351 |
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