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Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery

Despite careful preoperative planning, surgical flaps are prone to ischemic tissue damage and ischemia–reperfusion injury. The resulting wound breakdown and flap necrosis increase both treatment costs and patient morbidity. Hence, there is a need for strategies to promote flap survival and prevent i...

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Autores principales: Weinzierl, Andrea, Ampofo, Emmanuel, Menger, Michael D., Laschke, Matthias W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081973/
https://www.ncbi.nlm.nih.gov/pubmed/35548348
http://dx.doi.org/10.3389/fphar.2022.864351
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author Weinzierl, Andrea
Ampofo, Emmanuel
Menger, Michael D.
Laschke, Matthias W.
author_facet Weinzierl, Andrea
Ampofo, Emmanuel
Menger, Michael D.
Laschke, Matthias W.
author_sort Weinzierl, Andrea
collection PubMed
description Despite careful preoperative planning, surgical flaps are prone to ischemic tissue damage and ischemia–reperfusion injury. The resulting wound breakdown and flap necrosis increase both treatment costs and patient morbidity. Hence, there is a need for strategies to promote flap survival and prevent ischemia-induced tissue damage. Phytochemicals, defined as non-essential, bioactive, and plant-derived molecules, are attractive candidates for perioperative treatment as they have little to no side effects and are well tolerated by most patients. Furthermore, they have been shown to exert beneficial combinations of pro-angiogenic, anti-inflammatory, anti-oxidant, and anti-apoptotic effects. This review provides an overview of bioactive phytochemicals that have been used to increase flap survival in preclinical animal models and discusses the underlying molecular and cellular mechanisms.
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spelling pubmed-90819732022-05-10 Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery Weinzierl, Andrea Ampofo, Emmanuel Menger, Michael D. Laschke, Matthias W. Front Pharmacol Pharmacology Despite careful preoperative planning, surgical flaps are prone to ischemic tissue damage and ischemia–reperfusion injury. The resulting wound breakdown and flap necrosis increase both treatment costs and patient morbidity. Hence, there is a need for strategies to promote flap survival and prevent ischemia-induced tissue damage. Phytochemicals, defined as non-essential, bioactive, and plant-derived molecules, are attractive candidates for perioperative treatment as they have little to no side effects and are well tolerated by most patients. Furthermore, they have been shown to exert beneficial combinations of pro-angiogenic, anti-inflammatory, anti-oxidant, and anti-apoptotic effects. This review provides an overview of bioactive phytochemicals that have been used to increase flap survival in preclinical animal models and discusses the underlying molecular and cellular mechanisms. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9081973/ /pubmed/35548348 http://dx.doi.org/10.3389/fphar.2022.864351 Text en Copyright © 2022 Weinzierl, Ampofo, Menger and Laschke. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Weinzierl, Andrea
Ampofo, Emmanuel
Menger, Michael D.
Laschke, Matthias W.
Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery
title Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery
title_full Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery
title_fullStr Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery
title_full_unstemmed Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery
title_short Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery
title_sort tissue-protective mechanisms of bioactive phytochemicals in flap surgery
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081973/
https://www.ncbi.nlm.nih.gov/pubmed/35548348
http://dx.doi.org/10.3389/fphar.2022.864351
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