First Reported Case of Atypical Meningioma in an Individual with Down Syndrome

Individuals with Down syndrome are at decreased risk of developing most types of solid tumors, including central nervous system malignancies. Several mechanisms have been proposed to explain how additional genetic material on chromosome 21 may confer this increased protection. Only two individuals w...

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Autores principales: Vanderschelden, Rachel, Golshani, Kiarash, Evans, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Single Case − General Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082194/
https://www.ncbi.nlm.nih.gov/pubmed/35611359
http://dx.doi.org/10.1159/000523665
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author Vanderschelden, Rachel
Golshani, Kiarash
Evans, Mark G.
author_facet Vanderschelden, Rachel
Golshani, Kiarash
Evans, Mark G.
author_sort Vanderschelden, Rachel
collection PubMed
description Individuals with Down syndrome are at decreased risk of developing most types of solid tumors, including central nervous system malignancies. Several mechanisms have been proposed to explain how additional genetic material on chromosome 21 may confer this increased protection. Only two individuals with Down syndrome and meningioma have been described in the medical literature, whose tumors were both World Health Organization (WHO) grade 1. Here, we report the first individual with Down syndrome to our knowledge who developed an atypical meningioma, WHO grade 2. We also provide a hypothesis for how this tumor could have arisen in the setting of trisomy 21.
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spelling pubmed-90821942022-05-23 First Reported Case of Atypical Meningioma in an Individual with Down Syndrome Vanderschelden, Rachel Golshani, Kiarash Evans, Mark G. Case Rep Neurol Single Case − General Neurology Individuals with Down syndrome are at decreased risk of developing most types of solid tumors, including central nervous system malignancies. Several mechanisms have been proposed to explain how additional genetic material on chromosome 21 may confer this increased protection. Only two individuals with Down syndrome and meningioma have been described in the medical literature, whose tumors were both World Health Organization (WHO) grade 1. Here, we report the first individual with Down syndrome to our knowledge who developed an atypical meningioma, WHO grade 2. We also provide a hypothesis for how this tumor could have arisen in the setting of trisomy 21. S. Karger AG 2022-04-04 /pmc/articles/PMC9082194/ /pubmed/35611359 http://dx.doi.org/10.1159/000523665 Text en Copyright © 2022 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case − General Neurology
Vanderschelden, Rachel
Golshani, Kiarash
Evans, Mark G.
First Reported Case of Atypical Meningioma in an Individual with Down Syndrome
title First Reported Case of Atypical Meningioma in an Individual with Down Syndrome
title_full First Reported Case of Atypical Meningioma in an Individual with Down Syndrome
title_fullStr First Reported Case of Atypical Meningioma in an Individual with Down Syndrome
title_full_unstemmed First Reported Case of Atypical Meningioma in an Individual with Down Syndrome
title_short First Reported Case of Atypical Meningioma in an Individual with Down Syndrome
title_sort first reported case of atypical meningioma in an individual with down syndrome
topic Single Case − General Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082194/
https://www.ncbi.nlm.nih.gov/pubmed/35611359
http://dx.doi.org/10.1159/000523665
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AT evansmarkg firstreportedcaseofatypicalmeningiomainanindividualwithdownsyndrome

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