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Early deviant behaviour as a dimension trait and endophenotype in schizophrenia

BACKGROUND: In psychiatry, there is still a lack of objective biological diagnostic measurements. It is important to investigate measurements or symptom dimensions that can inform diagnostic assessments and allow for a more personalised approach to patients. AIM: To discuss how early deviant behavio...

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Detalles Bibliográficos
Autores principales: Roos, Johannes L., Kotzé, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082214/
https://www.ncbi.nlm.nih.gov/pubmed/35547101
http://dx.doi.org/10.4102/sajpsychiatry.v28i0.1747
Descripción
Sumario:BACKGROUND: In psychiatry, there is still a lack of objective biological diagnostic measurements. It is important to investigate measurements or symptom dimensions that can inform diagnostic assessments and allow for a more personalised approach to patients. AIM: To discuss how early deviant behaviour (EDB) may be seen as a possible continuous symptom dimension trait and endophenotype in schizophrenia. METHODS: Conducting a commentary review by highlighting some important findings from available literature. RESULTS: Findings regarding EDB in schizophrenia in a South African genetic sample point towards EDB as a progressive subtype of schizophrenia, with very early onset of illness (even prior to the psychotic symptomatology) and a genetic form of illness. CONCLUSION: Valuable information can be gained by enquiring into EDB and viewing it as a continuous symptom dimension trait and endophenotype during the psychiatric diagnostic interview.