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Correlates of high-dose antipsychotic prescription amongst outpatients with Schizophrenia in a Nigerian Hospital
BACKGROUND: Treatment guidelines recommend the use of antipsychotic monotherapy at effective doses for the treatment of schizophrenia, although about a third of the sufferers still receive high-dose antipsychotic treatment. Current evidence suggests that high-dose antipsychotic prescription (HDAP) n...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AOSIS
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082254/ https://www.ncbi.nlm.nih.gov/pubmed/35547105 http://dx.doi.org/10.4102/sajpsychiatry.v28i0.1791 |
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author | Anozie, Ihechiluru G. James, Bawo O. Omoaregba, Joyce O. Oriji, Sunday O. Erohubie, Paul O. Enebe, Anthony C. |
author_facet | Anozie, Ihechiluru G. James, Bawo O. Omoaregba, Joyce O. Oriji, Sunday O. Erohubie, Paul O. Enebe, Anthony C. |
author_sort | Anozie, Ihechiluru G. |
collection | PubMed |
description | BACKGROUND: Treatment guidelines recommend the use of antipsychotic monotherapy at effective doses for the treatment of schizophrenia, although about a third of the sufferers still receive high-dose antipsychotic treatment. Current evidence suggests that high-dose antipsychotic prescription (HDAP) not only fails to improve outcomes but also increases side effects. AIM: Our study aimed to determine the prevalence of HDAP and its association with illness severity, medication adherence behaviour and side effects amongst outpatients with schizophrenia. SETTING: The Federal Neuro-Psychiatric Hospital, Benin-City, Nigeria. METHODS: A cross-sectional study of 320 attendees with schizophrenia at the outpatient department was undertaken. We administered a sociodemographic and antipsychotic medication questionnaire, Mini-International Neuropsychiatric Interview, Positive and Negative Syndrome Scale, Liverpool University Neuroleptic Side Effects Rating Scales and Medication Adherence Rating Scales. High-dose antipsychotic prescription was determined by the ratio of prescribed daily dose to defined daily dose greater than 1.5. RESULTS: The prevalence of HDAP was 38.4%. Greater severity of illness, experiencing more side effects and poor medication adherence were significantly associated with HDAP.The major predictors of HDAP were antipsychotic polypharmacy and concurrent anticholinergic use. CONCLUSION: We conclude that although the use of HDAP amongst patients with schizophrenia remains common, its persistent use should be discouraged. |
format | Online Article Text |
id | pubmed-9082254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AOSIS |
record_format | MEDLINE/PubMed |
spelling | pubmed-90822542022-05-10 Correlates of high-dose antipsychotic prescription amongst outpatients with Schizophrenia in a Nigerian Hospital Anozie, Ihechiluru G. James, Bawo O. Omoaregba, Joyce O. Oriji, Sunday O. Erohubie, Paul O. Enebe, Anthony C. S Afr J Psychiatr Original Research BACKGROUND: Treatment guidelines recommend the use of antipsychotic monotherapy at effective doses for the treatment of schizophrenia, although about a third of the sufferers still receive high-dose antipsychotic treatment. Current evidence suggests that high-dose antipsychotic prescription (HDAP) not only fails to improve outcomes but also increases side effects. AIM: Our study aimed to determine the prevalence of HDAP and its association with illness severity, medication adherence behaviour and side effects amongst outpatients with schizophrenia. SETTING: The Federal Neuro-Psychiatric Hospital, Benin-City, Nigeria. METHODS: A cross-sectional study of 320 attendees with schizophrenia at the outpatient department was undertaken. We administered a sociodemographic and antipsychotic medication questionnaire, Mini-International Neuropsychiatric Interview, Positive and Negative Syndrome Scale, Liverpool University Neuroleptic Side Effects Rating Scales and Medication Adherence Rating Scales. High-dose antipsychotic prescription was determined by the ratio of prescribed daily dose to defined daily dose greater than 1.5. RESULTS: The prevalence of HDAP was 38.4%. Greater severity of illness, experiencing more side effects and poor medication adherence were significantly associated with HDAP.The major predictors of HDAP were antipsychotic polypharmacy and concurrent anticholinergic use. CONCLUSION: We conclude that although the use of HDAP amongst patients with schizophrenia remains common, its persistent use should be discouraged. AOSIS 2022-04-29 /pmc/articles/PMC9082254/ /pubmed/35547105 http://dx.doi.org/10.4102/sajpsychiatry.v28i0.1791 Text en © 2022. The Authors https://creativecommons.org/licenses/by/4.0/Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License. |
spellingShingle | Original Research Anozie, Ihechiluru G. James, Bawo O. Omoaregba, Joyce O. Oriji, Sunday O. Erohubie, Paul O. Enebe, Anthony C. Correlates of high-dose antipsychotic prescription amongst outpatients with Schizophrenia in a Nigerian Hospital |
title | Correlates of high-dose antipsychotic prescription amongst outpatients with Schizophrenia in a Nigerian Hospital |
title_full | Correlates of high-dose antipsychotic prescription amongst outpatients with Schizophrenia in a Nigerian Hospital |
title_fullStr | Correlates of high-dose antipsychotic prescription amongst outpatients with Schizophrenia in a Nigerian Hospital |
title_full_unstemmed | Correlates of high-dose antipsychotic prescription amongst outpatients with Schizophrenia in a Nigerian Hospital |
title_short | Correlates of high-dose antipsychotic prescription amongst outpatients with Schizophrenia in a Nigerian Hospital |
title_sort | correlates of high-dose antipsychotic prescription amongst outpatients with schizophrenia in a nigerian hospital |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082254/ https://www.ncbi.nlm.nih.gov/pubmed/35547105 http://dx.doi.org/10.4102/sajpsychiatry.v28i0.1791 |
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