Drug-likeness of linear pentamidine analogues and their impact on the hERG K(+) channel – correlation with structural features

This work presents drug-likeness and the cardiotoxicity profiles of six potent pentamidine analogs 1–6 and three new compounds 7–9 as chemotherapeutics for therapy of Pneumocystis jiroveci pneumonia. A combination of experimental and computational approaches was used in the cardiotoxicity examinatio...

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Detalles Bibliográficos
Autores principales: Żołek, Teresa, Qile, Muge, Kaźmierczak, Paweł, Bloothooft, Meye, van der Heyden, Marcel A. G., Maciejewska, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082326/
https://www.ncbi.nlm.nih.gov/pubmed/35540224
http://dx.doi.org/10.1039/c9ra08404e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082326/
https://www.ncbi.nlm.nih.gov/pubmed/35540224
http://dx.doi.org/10.1039/c9ra08404e

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