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Drug-likeness of linear pentamidine analogues and their impact on the hERG K(+) channel – correlation with structural features
This work presents drug-likeness and the cardiotoxicity profiles of six potent pentamidine analogs 1–6 and three new compounds 7–9 as chemotherapeutics for therapy of Pneumocystis jiroveci pneumonia. A combination of experimental and computational approaches was used in the cardiotoxicity examinatio...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082326/ https://www.ncbi.nlm.nih.gov/pubmed/35540224 http://dx.doi.org/10.1039/c9ra08404e |