Pre-clinical pharmacokinetic-pharmacodynamic modelling and biodistribution studies of donepezil hydrochloride by a validated HPLC method

A simple, sensitive and robust HPLC–PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent acetylcholinesterase inhibitor in rat plasma and tissues. All biological samples were prepared by the solid-phase extraction method using loratadine as an inte...

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Detalles Bibliográficos
Autores principales: Krishna, Kowthavarapu Venkata, Saha, Ranendra Narayana, Singhvi, Gautam, Dubey, Sunil Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082346/
https://www.ncbi.nlm.nih.gov/pubmed/35542150
http://dx.doi.org/10.1039/c8ra03379j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082346/
https://www.ncbi.nlm.nih.gov/pubmed/35542150
http://dx.doi.org/10.1039/c8ra03379j

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