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Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease
Blood‐based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were classified as biomarker positive (Ptau+) or negative (Ptau‐) based on Ptau 181 and 217 concentrations and as cogniti...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082382/ https://www.ncbi.nlm.nih.gov/pubmed/35306760 http://dx.doi.org/10.1002/acn3.51529 |
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| author | Brickman, Adam M. Manly, Jennifer J. Honig, Lawrence S. Sanchez, Danurys Reyes‐Dumeyer, Dolly Lantigua, Rafael A. Vonsattel, Jean Paul Teich, Andrew F. Kang, Min Suk Dage, Jeffrey L. Mayeux, Richard |
| author_facet | Brickman, Adam M. Manly, Jennifer J. Honig, Lawrence S. Sanchez, Danurys Reyes‐Dumeyer, Dolly Lantigua, Rafael A. Vonsattel, Jean Paul Teich, Andrew F. Kang, Min Suk Dage, Jeffrey L. Mayeux, Richard |
| author_sort | Brickman, Adam M. |
| collection | PubMed |
| description | Blood‐based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were classified as biomarker positive (Ptau+) or negative (Ptau‐) based on Ptau 181 and 217 concentrations and as cognitively impaired (Sym) or unimpaired (Asym). The four groups, Ptau‐/Asym, Ptau+/Asym, Ptau‐/Sym, and Ptau+/Sym, differed by age, APOE‐4 allele frequency, total tau, neurofilament light chain, and cortical thickness measured by MRI. Our results add to increasing evidence that plasma Ptau 181 and 217 concentrations are valid Alzheimer's disease biomarkers in diverse populations. |
| format | Online Article Text |
| id | pubmed-9082382 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90823822022-05-16 Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease Brickman, Adam M. Manly, Jennifer J. Honig, Lawrence S. Sanchez, Danurys Reyes‐Dumeyer, Dolly Lantigua, Rafael A. Vonsattel, Jean Paul Teich, Andrew F. Kang, Min Suk Dage, Jeffrey L. Mayeux, Richard Ann Clin Transl Neurol Brief Communications Blood‐based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were classified as biomarker positive (Ptau+) or negative (Ptau‐) based on Ptau 181 and 217 concentrations and as cognitively impaired (Sym) or unimpaired (Asym). The four groups, Ptau‐/Asym, Ptau+/Asym, Ptau‐/Sym, and Ptau+/Sym, differed by age, APOE‐4 allele frequency, total tau, neurofilament light chain, and cortical thickness measured by MRI. Our results add to increasing evidence that plasma Ptau 181 and 217 concentrations are valid Alzheimer's disease biomarkers in diverse populations. John Wiley and Sons Inc. 2022-03-20 /pmc/articles/PMC9082382/ /pubmed/35306760 http://dx.doi.org/10.1002/acn3.51529 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| spellingShingle | Brief Communications Brickman, Adam M. Manly, Jennifer J. Honig, Lawrence S. Sanchez, Danurys Reyes‐Dumeyer, Dolly Lantigua, Rafael A. Vonsattel, Jean Paul Teich, Andrew F. Kang, Min Suk Dage, Jeffrey L. Mayeux, Richard Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease |
| title | Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease |
| title_full | Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease |
| title_fullStr | Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease |
| title_full_unstemmed | Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease |
| title_short | Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease |
| title_sort | correlation of plasma and neuroimaging biomarkers in alzheimer's disease |
| topic | Brief Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082382/ https://www.ncbi.nlm.nih.gov/pubmed/35306760 http://dx.doi.org/10.1002/acn3.51529 |
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