Cargando…

Hold that pose: capturing cervical dystonia's head deviation severity from video

OBJECTIVE: Deviated head posture is a defining characteristic of cervical dystonia (CD). Head posture severity is typically quantified with clinical rating scales such as the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Because clinical rating scales are inherently subjective, they a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Zheng, Cisneros, Elizabeth, Lee, Ha Yeon, Vu, Jeanne P., Chen, Qiyu, Benadof, Casey N., Whitehill, Jacob, Rouzbehani, Ryin, Sy, Dominique T., Huang, Jeannie S., Sejnowski, Terrence J., Jankovic, Joseph, Factor, Stewart, Goetz, Christopher G., Barbano, Richard L., Perlmutter, Joel S., Jinnah, Hyder A., Berman, Brian D., Richardson, Sarah Pirio, Stebbins, Glenn T., Comella, Cynthia L., Peterson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082391/
https://www.ncbi.nlm.nih.gov/pubmed/35333449
http://dx.doi.org/10.1002/acn3.51549
_version_ 1784703195054866432
author Zhang, Zheng
Cisneros, Elizabeth
Lee, Ha Yeon
Vu, Jeanne P.
Chen, Qiyu
Benadof, Casey N.
Whitehill, Jacob
Rouzbehani, Ryin
Sy, Dominique T.
Huang, Jeannie S.
Sejnowski, Terrence J.
Jankovic, Joseph
Factor, Stewart
Goetz, Christopher G.
Barbano, Richard L.
Perlmutter, Joel S.
Jinnah, Hyder A.
Berman, Brian D.
Richardson, Sarah Pirio
Stebbins, Glenn T.
Comella, Cynthia L.
Peterson, David A.
author_facet Zhang, Zheng
Cisneros, Elizabeth
Lee, Ha Yeon
Vu, Jeanne P.
Chen, Qiyu
Benadof, Casey N.
Whitehill, Jacob
Rouzbehani, Ryin
Sy, Dominique T.
Huang, Jeannie S.
Sejnowski, Terrence J.
Jankovic, Joseph
Factor, Stewart
Goetz, Christopher G.
Barbano, Richard L.
Perlmutter, Joel S.
Jinnah, Hyder A.
Berman, Brian D.
Richardson, Sarah Pirio
Stebbins, Glenn T.
Comella, Cynthia L.
Peterson, David A.
author_sort Zhang, Zheng
collection PubMed
description OBJECTIVE: Deviated head posture is a defining characteristic of cervical dystonia (CD). Head posture severity is typically quantified with clinical rating scales such as the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Because clinical rating scales are inherently subjective, they are susceptible to variability that reduces their sensitivity as outcome measures. The variability could be circumvented with methods to measure CD head posture objectively. However, previously used objective methods require specialized equipment and have been limited to studies with a small number of cases. The objective of this study was to evaluate a novel software system—the Computational Motor Objective Rater (CMOR)—to quantify multi‐axis directionality and severity of head posture in CD using only conventional video camera recordings. METHODS: CMOR is based on computer vision and machine learning technology that captures 3D head angle from video. We used CMOR to quantify the axial patterns and severity of predominant head posture in a retrospective, cross‐sectional study of 185 patients with isolated CD recruited from 10 sites in the Dystonia Coalition. RESULTS: The predominant head posture involved more than one axis in 80.5% of patients and all three axes in 44.4%. CMOR's metrics for head posture severity correlated with severity ratings from movement disorders neurologists using both the TWSTRS‐2 and an adapted version of the Global Dystonia Rating Scale (rho = 0.59–0.68, all p <0.001). CONCLUSIONS: CMOR's convergent validity with clinical rating scales and reliance upon only conventional video recordings supports its future potential for large scale multisite clinical trials.
format Online
Article
Text
id pubmed-9082391
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-90823912022-05-16 Hold that pose: capturing cervical dystonia's head deviation severity from video Zhang, Zheng Cisneros, Elizabeth Lee, Ha Yeon Vu, Jeanne P. Chen, Qiyu Benadof, Casey N. Whitehill, Jacob Rouzbehani, Ryin Sy, Dominique T. Huang, Jeannie S. Sejnowski, Terrence J. Jankovic, Joseph Factor, Stewart Goetz, Christopher G. Barbano, Richard L. Perlmutter, Joel S. Jinnah, Hyder A. Berman, Brian D. Richardson, Sarah Pirio Stebbins, Glenn T. Comella, Cynthia L. Peterson, David A. Ann Clin Transl Neurol Research Articles OBJECTIVE: Deviated head posture is a defining characteristic of cervical dystonia (CD). Head posture severity is typically quantified with clinical rating scales such as the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Because clinical rating scales are inherently subjective, they are susceptible to variability that reduces their sensitivity as outcome measures. The variability could be circumvented with methods to measure CD head posture objectively. However, previously used objective methods require specialized equipment and have been limited to studies with a small number of cases. The objective of this study was to evaluate a novel software system—the Computational Motor Objective Rater (CMOR)—to quantify multi‐axis directionality and severity of head posture in CD using only conventional video camera recordings. METHODS: CMOR is based on computer vision and machine learning technology that captures 3D head angle from video. We used CMOR to quantify the axial patterns and severity of predominant head posture in a retrospective, cross‐sectional study of 185 patients with isolated CD recruited from 10 sites in the Dystonia Coalition. RESULTS: The predominant head posture involved more than one axis in 80.5% of patients and all three axes in 44.4%. CMOR's metrics for head posture severity correlated with severity ratings from movement disorders neurologists using both the TWSTRS‐2 and an adapted version of the Global Dystonia Rating Scale (rho = 0.59–0.68, all p <0.001). CONCLUSIONS: CMOR's convergent validity with clinical rating scales and reliance upon only conventional video recordings supports its future potential for large scale multisite clinical trials. John Wiley and Sons Inc. 2022-03-25 /pmc/articles/PMC9082391/ /pubmed/35333449 http://dx.doi.org/10.1002/acn3.51549 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Zhang, Zheng
Cisneros, Elizabeth
Lee, Ha Yeon
Vu, Jeanne P.
Chen, Qiyu
Benadof, Casey N.
Whitehill, Jacob
Rouzbehani, Ryin
Sy, Dominique T.
Huang, Jeannie S.
Sejnowski, Terrence J.
Jankovic, Joseph
Factor, Stewart
Goetz, Christopher G.
Barbano, Richard L.
Perlmutter, Joel S.
Jinnah, Hyder A.
Berman, Brian D.
Richardson, Sarah Pirio
Stebbins, Glenn T.
Comella, Cynthia L.
Peterson, David A.
Hold that pose: capturing cervical dystonia's head deviation severity from video
title Hold that pose: capturing cervical dystonia's head deviation severity from video
title_full Hold that pose: capturing cervical dystonia's head deviation severity from video
title_fullStr Hold that pose: capturing cervical dystonia's head deviation severity from video
title_full_unstemmed Hold that pose: capturing cervical dystonia's head deviation severity from video
title_short Hold that pose: capturing cervical dystonia's head deviation severity from video
title_sort hold that pose: capturing cervical dystonia's head deviation severity from video
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082391/
https://www.ncbi.nlm.nih.gov/pubmed/35333449
http://dx.doi.org/10.1002/acn3.51549
work_keys_str_mv AT zhangzheng holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT cisneroselizabeth holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT leehayeon holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT vujeannep holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT chenqiyu holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT benadofcaseyn holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT whitehilljacob holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT rouzbehaniryin holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT sydominiquet holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT huangjeannies holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT sejnowskiterrencej holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT jankovicjoseph holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT factorstewart holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT goetzchristopherg holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT barbanorichardl holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT perlmutterjoels holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT jinnahhydera holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT bermanbriand holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT richardsonsarahpirio holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT stebbinsglennt holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT comellacynthial holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo
AT petersondavida holdthatposecapturingcervicaldystoniasheaddeviationseverityfromvideo