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Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana

Six new guaiane dimers, xyloplains A–F (1–6), with connecting patterns through two direct C–C bonds (C-1 to C-3′, C-2 to C-1′), were isolated from the roots of Xylopia vielana. Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffracti...

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Autores principales: Xie, Yang-Guo, Zhang, Weiyue, Zhu, Sheng-lan, Cheng, Tao-fang, Wu, Guo-jing, Muhammad, Ishaq, Yan, Shi-kai, Zhang, Yan, Jin, Hui-zi, Zhang, Wei-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082531/
https://www.ncbi.nlm.nih.gov/pubmed/35539790
http://dx.doi.org/10.1039/c8ra04356f
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author Xie, Yang-Guo
Zhang, Weiyue
Zhu, Sheng-lan
Cheng, Tao-fang
Wu, Guo-jing
Muhammad, Ishaq
Yan, Shi-kai
Zhang, Yan
Jin, Hui-zi
Zhang, Wei-dong
author_facet Xie, Yang-Guo
Zhang, Weiyue
Zhu, Sheng-lan
Cheng, Tao-fang
Wu, Guo-jing
Muhammad, Ishaq
Yan, Shi-kai
Zhang, Yan
Jin, Hui-zi
Zhang, Wei-dong
author_sort Xie, Yang-Guo
collection PubMed
description Six new guaiane dimers, xyloplains A–F (1–6), with connecting patterns through two direct C–C bonds (C-1 to C-3′, C-2 to C-1′), were isolated from the roots of Xylopia vielana. Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffraction and circular dichroism (CD) experiments. In additon, all of the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide produced. To our delight, compounds 2 and 6 exhibited moderate inhibitory activity against the production of nitric oxide with IC(50) value of 34.5 and 31.1 μM, respectively, in RAW264.7 cells stimulated by LPS.
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spelling pubmed-90825312022-05-09 Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana Xie, Yang-Guo Zhang, Weiyue Zhu, Sheng-lan Cheng, Tao-fang Wu, Guo-jing Muhammad, Ishaq Yan, Shi-kai Zhang, Yan Jin, Hui-zi Zhang, Wei-dong RSC Adv Chemistry Six new guaiane dimers, xyloplains A–F (1–6), with connecting patterns through two direct C–C bonds (C-1 to C-3′, C-2 to C-1′), were isolated from the roots of Xylopia vielana. Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffraction and circular dichroism (CD) experiments. In additon, all of the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide produced. To our delight, compounds 2 and 6 exhibited moderate inhibitory activity against the production of nitric oxide with IC(50) value of 34.5 and 31.1 μM, respectively, in RAW264.7 cells stimulated by LPS. The Royal Society of Chemistry 2018-07-18 /pmc/articles/PMC9082531/ /pubmed/35539790 http://dx.doi.org/10.1039/c8ra04356f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Xie, Yang-Guo
Zhang, Weiyue
Zhu, Sheng-lan
Cheng, Tao-fang
Wu, Guo-jing
Muhammad, Ishaq
Yan, Shi-kai
Zhang, Yan
Jin, Hui-zi
Zhang, Wei-dong
Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana
title Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana
title_full Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana
title_fullStr Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana
title_full_unstemmed Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana
title_short Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana
title_sort xyloplains a–f, six new guaiane-type sesquiterpenoid dimers from xylopia vielana
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082531/
https://www.ncbi.nlm.nih.gov/pubmed/35539790
http://dx.doi.org/10.1039/c8ra04356f
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