Cargando…
Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana
Six new guaiane dimers, xyloplains A–F (1–6), with connecting patterns through two direct C–C bonds (C-1 to C-3′, C-2 to C-1′), were isolated from the roots of Xylopia vielana. Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffracti...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082531/ https://www.ncbi.nlm.nih.gov/pubmed/35539790 http://dx.doi.org/10.1039/c8ra04356f |
_version_ | 1784703221929869312 |
---|---|
author | Xie, Yang-Guo Zhang, Weiyue Zhu, Sheng-lan Cheng, Tao-fang Wu, Guo-jing Muhammad, Ishaq Yan, Shi-kai Zhang, Yan Jin, Hui-zi Zhang, Wei-dong |
author_facet | Xie, Yang-Guo Zhang, Weiyue Zhu, Sheng-lan Cheng, Tao-fang Wu, Guo-jing Muhammad, Ishaq Yan, Shi-kai Zhang, Yan Jin, Hui-zi Zhang, Wei-dong |
author_sort | Xie, Yang-Guo |
collection | PubMed |
description | Six new guaiane dimers, xyloplains A–F (1–6), with connecting patterns through two direct C–C bonds (C-1 to C-3′, C-2 to C-1′), were isolated from the roots of Xylopia vielana. Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffraction and circular dichroism (CD) experiments. In additon, all of the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide produced. To our delight, compounds 2 and 6 exhibited moderate inhibitory activity against the production of nitric oxide with IC(50) value of 34.5 and 31.1 μM, respectively, in RAW264.7 cells stimulated by LPS. |
format | Online Article Text |
id | pubmed-9082531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90825312022-05-09 Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana Xie, Yang-Guo Zhang, Weiyue Zhu, Sheng-lan Cheng, Tao-fang Wu, Guo-jing Muhammad, Ishaq Yan, Shi-kai Zhang, Yan Jin, Hui-zi Zhang, Wei-dong RSC Adv Chemistry Six new guaiane dimers, xyloplains A–F (1–6), with connecting patterns through two direct C–C bonds (C-1 to C-3′, C-2 to C-1′), were isolated from the roots of Xylopia vielana. Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffraction and circular dichroism (CD) experiments. In additon, all of the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide produced. To our delight, compounds 2 and 6 exhibited moderate inhibitory activity against the production of nitric oxide with IC(50) value of 34.5 and 31.1 μM, respectively, in RAW264.7 cells stimulated by LPS. The Royal Society of Chemistry 2018-07-18 /pmc/articles/PMC9082531/ /pubmed/35539790 http://dx.doi.org/10.1039/c8ra04356f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Xie, Yang-Guo Zhang, Weiyue Zhu, Sheng-lan Cheng, Tao-fang Wu, Guo-jing Muhammad, Ishaq Yan, Shi-kai Zhang, Yan Jin, Hui-zi Zhang, Wei-dong Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana |
title | Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana |
title_full | Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana |
title_fullStr | Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana |
title_full_unstemmed | Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana |
title_short | Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana |
title_sort | xyloplains a–f, six new guaiane-type sesquiterpenoid dimers from xylopia vielana |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082531/ https://www.ncbi.nlm.nih.gov/pubmed/35539790 http://dx.doi.org/10.1039/c8ra04356f |
work_keys_str_mv | AT xieyangguo xyloplainsafsixnewguaianetypesesquiterpenoiddimersfromxylopiavielana AT zhangweiyue xyloplainsafsixnewguaianetypesesquiterpenoiddimersfromxylopiavielana AT zhushenglan xyloplainsafsixnewguaianetypesesquiterpenoiddimersfromxylopiavielana AT chengtaofang xyloplainsafsixnewguaianetypesesquiterpenoiddimersfromxylopiavielana AT wuguojing xyloplainsafsixnewguaianetypesesquiterpenoiddimersfromxylopiavielana AT muhammadishaq xyloplainsafsixnewguaianetypesesquiterpenoiddimersfromxylopiavielana AT yanshikai xyloplainsafsixnewguaianetypesesquiterpenoiddimersfromxylopiavielana AT zhangyan xyloplainsafsixnewguaianetypesesquiterpenoiddimersfromxylopiavielana AT jinhuizi xyloplainsafsixnewguaianetypesesquiterpenoiddimersfromxylopiavielana AT zhangweidong xyloplainsafsixnewguaianetypesesquiterpenoiddimersfromxylopiavielana |