Palladium-catalyzed direct C(sp(3))–H arylation of indole-3-ones with aryl halides: a novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones

A novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones via palladium-catalyzed direct C(sp(3))–H arylation of indole-3-ones with aryl halides has been developed. Various 2-monoarylated indole-3-ones were readily obtained with yields up to 95%. As a class of impor...

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Detalles Bibliográficos
Autores principales: Zhao, Yong-Long, Tang, Yong-Qin, Fei, Xing-Hai, Xiao, Tao, Lu, Ya-Dong, Fu, Xiao-Zhong, He, Bin, Zhou, Meng, Li, Chun, Xu, Peng-Fei, Yang, Yuan-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082533/
https://www.ncbi.nlm.nih.gov/pubmed/35539771
http://dx.doi.org/10.1039/c8ra04807j
Descripción
Sumario:A novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones via palladium-catalyzed direct C(sp(3))–H arylation of indole-3-ones with aryl halides has been developed. Various 2-monoarylated indole-3-ones were readily obtained with yields up to 95%. As a class of important nucleophilic intermediates, 2-monoarylated indole-3-ones can be used for the construction of C2-quaternary indolin-3-one skeletons.

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