In vivo Overexpression of Electrogenic Sodium/Bicarbonate Cotransporter (NBCe1) by AAV9 Modifies the Cardiac Action Potential and the QT Interval in Mice

Cardiac cells depend on specific sarcolemmal ion transporters to assure the correct intracellular pH regulation. The sodium/bicarbonate cotransporter (NBC) is one of the major alkalinizing mechanisms. In the heart two different NBC isoforms have been described: the electroneutral NBCn1 (1Na(+):1 [Fo...

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Detalles Bibliográficos
Autores principales: Di Mattía, Romina A., Díaz Zegarra, Leandro A., Valverde, Carlos A., Blanco, Paula G., Jaquenod De Giusti, Carolina, Portiansky, Enrique L., Aiello, Ernesto A., Orlowski, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082548/
https://www.ncbi.nlm.nih.gov/pubmed/35548416
http://dx.doi.org/10.3389/fcvm.2022.862118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082548/
https://www.ncbi.nlm.nih.gov/pubmed/35548416
http://dx.doi.org/10.3389/fcvm.2022.862118

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